Short‐acting β2‐adrenergic receptor agonists are commonly used bronchodilators for
symptom relief in asthmatics. Recent evidence demonstrated that prolonged exposure of …

Although short-acting and long-acting inhaled β 2-adrenergic receptor agonists (SABA and
LABA, respectively) relieve asthma symptoms, use of either agent alone without concomitant …

Background Regulator of G protein signaling (RGS) 2 terminates bronchoconstrictive Gαq
signaling; murine RGS2 knockout demonstrate airway hyperresponsiveness. While RGS2 …

Genetic variation may partly explain asthma treatment response heterogeneity. We aimed to
identify common and rare genetic variants associated with asthma that was not well …

Asthma is a polygenic disease that may onset during childhood. Inhaled corticosteroids
(ICS) are the main therapy in asthma, although their efficacy varies among individuals …

β2-adrenergic receptors (β2AR) are GTP-binding protein (G-protein) coupled receptors
widely distributed in human tissue. Inhaled β2-agonist drugs exert their primary effect on the …

Abstract Background and Objectives Genome Wide Association Studies (GWAS) have
identified genetic polymorphisms associated with bronchodilator response (BDR), but it is …

Asthma is a chronic respiratory disease that affects 339 million people worldwide and has a
considerable impact on the pediatric population. Asthma symptoms can be controlled by …

Short-acting b2-adrenergic receptor agonists are commonly used bronchodilators for
symptom relief in asthmatics. The aim of this study was to test whether genetic variants in …

Beta-agonist treatment of asthma displays substantial interindividual variation, which has
prompted polymorphism discovery and characterization of β 2-adrenergic (β 2 AR) signaling …