Protein post-translational modifications (PTMs) are important regulators of protein functions
and produce proteome complexity. SIRT1 has NAD+-dependent deacylation of acyl-lysine …

Aims A complex set of metabolic and inflammatory processes are involved in the
development of cardiac hypertrophy. Accumulating evidence indicates an important role for …

Cellular metabolites, such as acyl-CoA, can modify proteins, leading to protein
posttranslational modifications (PTMs). One such PTM is lysine succinylation, which is …

Background Metabolic cardiomyopathy (MCM), characterized by intramyocardial lipid
accumulation, drives the progression to heart failure with preserved ejection fraction …

High-fat diet leads to development of cardiac dysfunction through molecular mechanisms
poorly known. The aim of this study is to elucidate the early events in cardiac dysfunction …

High energy production in mitochondria is essential for maintaining cardiac contraction in
the heart. Genes regulating mitochondrial function are commonly downregulated during …

Cardiac remodeling is the primary pathological feature of chronic heart failure (HF).
Exploring the characteristics of cardiac remodeling in the very early stages of HF and …

Cardiac hypertrophy is an adaptive response to pressure, volume stress, and loss of
contractile mass from prior infarction. Metabolic changes in cardiac hypertrophy include …

Calorie restriction is considered to be the best environmental intervention providing health
benefits to mammals. The underlying mechanism of this intervention seems to be controlled …

Abstract Sirtuin 3 (SIRT3) is a type III histone deacetylase that inhibits cardiac hypertrophy. It
is mainly localized in the mitochondria and is thus implicated in mitochondrial metabolism …