Alternative splicing is a critical process to generate protein diversity. However, whether and
how alternative splicing regulates autophagy remains largely elusive. Here we …

Most tumor cells take up more glucose than normal cells. Splicing dysregulation is one of the
molecular hallmarks of cancer. However, the role of splicing factor in glucose metabolism …

Objective To investigate the molecular function of splicing factor SRSF6 in colorectal cancer
(CRC) progression and discover candidate chemicals for cancer therapy through targeting …

In lung adenocarcinoma (LUAD), loss-of-function mutations in the splicing factor RBM10
frequently co-occur with oncogenic EGFR mutations. A detailed understanding of the …

Increasing evidence points to the functional importance of alternative splice variations in
cancer pathophysiology with the alternative pre-mRNA processing of caspase 9 as one …

Aberrant RNA splicing is recognized to contribute to cancer pathogenesis, but the
underlying mechanisms remain mainly obscure. Here, we report that the splicing factor …

As the modulation of serine/arginine-rich splicing factor 3 (SRSF3) may be therapeutically
beneficial to colorectal cancer (CRC) treatment, the identification of novel SRSF3 inhibitors …

Splicing factor SRSF1 is upregulated in human breast tumors, and its overexpression
promotes transformation of mammary cells. Using RNA-seq, we identified SRSF1-regulated …

Serine/arginine-rich splicing factor 3 (SRSF3) likely has wide-ranging roles in gene
expression and facilitation of tumor cell growth. SRSF3 knockdown induced G1 arrest and …

Macroautophagy/autophagy is a multistep cellular process that sequesters cytoplasmic
components for lysosomal degradation. BECN1/Beclin1 is a central protein that assembles …