We conducted comprehensive integrative molecular analyses of the complete set of tumors
in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and …

Abstract The Cancer Genome Atlas (TCGA) represents one of several international consortia
dedicated to performing comprehensive genomic and epigenomic analyses of selected …

Substantial evidence supports the concept that cancers are organized in a cellular hierarchy
with cancer stem cells (CSC) at the apex. To date, the primary evidence for CSCs derives …

Recent genomic analyses of pathologically defined tumor types identify" within-a-tissue"
disease subtypes. However, the extent to which genomic signatures are shared across …

The comparison of DNA methylation patterns across cancer types (pan-cancer methylome
analyses) has revealed distinct subgroups of tumors that share similar methylation patterns …

Defining the pathways through which tumors progress is critical to our understanding and
treatment of cancer. We do not routinely sample patients at multiple time points during the …

Genome-wide expression profiling studies reveal a transcriptionally distinct sub-type of
human solid tumors with a marked propensity toward metastatic dissemination, highly …

Abstract Purpose: The Cancer Genome Atlas data resources represent an opportunity to
explore commonalities across cancer types involving multiple molecular levels, but tumor …

Cancer comprises a bewildering assortment of diseases that kill 7.5 million people each
year. Poor understanding of cancer's diversity currently thwarts our goal of a cure for every …

Abstract Background The Cancer Genome Atlas (TCGA) offers a multilayered view of
genomics and epigenomics data of many human cancer types. However, the retrieval of …