Creation and application of virtual patient cohorts of heart models

SA Niederer, Y Aboelkassem… - … of the Royal …, 2020 - royalsocietypublishing.org
Patient-specific cardiac models are now being used to guide therapies. The increased use
of patient-specific cardiac simulations in clinical care will give rise to the development of …

Uncertainty and variability in computational and mathematical models of cardiac physiology

GR Mirams, P Pathmanathan, RA Gray… - The Journal of …, 2016 - Wiley Online Library
Key points Mathematical and computational models of cardiac physiology have been an
integral component of cardiac electrophysiology since its inception, and are collectively …

Ensuring reliability of safety-critical clinical applications of computational cardiac models

P Pathmanathan, RA Gray - Frontiers in physiology, 2013 - frontiersin.org
Computational models of cardiac electrophysiology have been used for over half a century
to investigate physiological mechanisms and generate hypotheses for experimental testing …

Credibility assessment of patient-specific computational modeling using patient-specific cardiac modeling as an exemplar

S Galappaththige, RA Gray, CM Costa… - PLoS computational …, 2022 - journals.plos.org
Reliable and robust simulation of individual patients using patient-specific models (PSMs) is
one of the next frontiers for modeling and simulation (M&S) in healthcare. PSMs, which form …

Uncertainty quantification and sensitivity analysis of left ventricular function during the full cardiac cycle

JO Campos, J Sundnes… - … Transactions of the …, 2020 - royalsocietypublishing.org
Patient-specific computer simulations can be a powerful tool in clinical applications, helping
in diagnostics and the development of new treatments. However, its practical use depends …

[HTML][HTML] Computational fluid dynamics modelling in cardiovascular medicine

PD Morris, A Narracott, H von Tengg-Kobligk… - Heart, 2016 - heart.bmj.com
This paper reviews the methods, benefits and challenges associated with the adoption and
translation of computational fluid dynamics (CFD) modelling within cardiovascular medicine …

Computational models in cardiology

SA Niederer, J Lumens, NA Trayanova - Nature reviews cardiology, 2019 - nature.com
The treatment of individual patients in cardiology practice increasingly relies on advanced
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …

Toward patient-specific myocardial models of the heart

M Sermesant, JM Peyrat, P Chinchapatnam, F Billet… - Heart failure clinics, 2008 - Elsevier
This article presents a framework for building patient-specific models of the myocardium, to
help diagnosis, therapy planning, and procedure guidance. The aim is to be able to …

What is needed to make cardiovascular models suitable for clinical decision support? A viewpoint paper

W Huberts, SGH Heinen, N Zonnebeld… - Journal of computational …, 2018 - Elsevier
The potential impact of hemodynamic and vascular wall models on the diagnosis, treatment,
and well-being of thousands of patients suffering from cardiovascular diseases, is …

How personalized heart modeling can help treatment of lethal arrhythmias: A focus on ventricular tachycardia ablation strategies in post‐infarction patients

NA Trayanova, AN Doshi… - … Reviews: Systems Biology …, 2020 - Wiley Online Library
Precision Cardiology is a targeted strategy for cardiovascular disease prevention and
treatment that accounts for individual variability. Computational heart modeling is one of the …