We discuss the upstream regulators of myogenesis that lead to the activation of myogenic
determination genes and subsequent differentiation, focusing on the mouse model. Key …

Recent genetic and biochemical approaches have advanced our understanding of control
mechanisms underlying myogenesis in vertebrate organisms. In particular, systematic …

Commitment of progenitors in the dermomyotome to myoblast fate is the first step in
establishing the body musculature. Pax3 is a crucial transcription factor, important for …

Myogenesis has been a leading model for elucidating the molecular mechanisms that
underlie tissue differentiation and development since the discovery of MyoD. During …

Since the seminal discovery of the cell-fate regulator Myod, studies in skeletal myogenesis
have inspired the search for cell-fate regulators of similar potential in other tissues and …

MyoD is a master regulator of the skeletal muscle gene expression program. ChIP-Seq
analysis has recently revealed that MyoD binds to a large number of genomic loci in …

Skeletal muscle in vertebrates is formed by two major routes, as illustrated by the mouse
embryo. Somites give rise to myogenic progenitors that form all of the muscles of the trunk …

The development and differentiation of distinct cell types is achieved through the sequential
expression of subsets of genes; yet, the molecular mechanisms that temporally pattern gene …

The Pax7 transcription factor is required for muscle satellite cell biogenesis and specification
of the myogenic precursor lineage. Pax7 is expressed in proliferating myoblasts but is …

Summary Although FoxO and Pax proteins represent two important families of transcription
factors in determining cell fate, they had not been functionally or physically linked together in …