Copper in Hepatocyte Functions and Fat Metabolism: Protection from Hepatic Lipid Toxicity by Copper Homeostasis

J Brake - 2023 - search.proquest.com
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a progressive liver disorder
with comorbidities like obesity, type-2 diabetes, and cardiovascular disease. Given that …

The role of insufficient copper in lipid synthesis and fatty‐liver disease

A Morrell, S Tallino, L Yu, JL Burkhead - IUBMB life, 2017 - Wiley Online Library
The essential transition metal copper is important in lipid metabolism, redox balance, iron
mobilization, and many other critical processes in eukaryotic organisms. Genetic diseases …

HIGH FRUCTOSE FEEDING INDUCES COPPER DEFICIENCY: A NOVEL MECHANISM FOR OBESITY RELATED FATTY LIVER: 1543

M Song, D Schuschke, Z Zhou, TS Chen, R Wang… - Hepatology, 2010 - journals.lww.com
Background/Aims: Dietary copper deficiency is associated with a variety of signs/symptoms
of the metabolic syndrome, including hyperlipidemia and fatty liver. Older nutrition literature …

High fructose feeding induces copper deficiency in Sprague–Dawley rats: a novel mechanism for obesity related fatty liver

M Song, DA Schuschke, Z Zhou, T Chen… - Journal of …, 2012 - Elsevier
BACKGROUND & AIMS: Dietary copper deficiency is associated with a variety of
manifestations of the metabolic syndrome, including hyperlipidemia and fatty liver. Fructose …

Fructose aggravates copper-deficiency-induced non-alcoholic fatty liver disease

X Jiang, R Hu, Y Huang, Y Xu, Z Zheng, Y Shi… - The Journal of …, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD), is the most common cause of chronic liver
disease, affecting 24% of the global population. Accumulating evidence demonstrates that …

[HTML][HTML] Deficient copper concentrations in dried-defatted hepatic tissue from ob/ob mice: A potential model for study of defective copper regulation in metabolic liver …

SJ Church, P Begley, N Kureishy, S McHarg… - Biochemical and …, 2015 - Elsevier
Ob/ob mice provide an animal model for non-alcoholic fatty liver disease/non-alcoholic
steatohepatitis (NAFLD/NASH) in patients with obesity and type-2 diabetes. Low liver copper …

Non-alcoholic fatty liver disease and nutritional implications: special focus on copper

L Antonucci, C Porcu, G Iannucci, C Balsano… - Nutrients, 2017 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is characterized by excess lipids in hepatocytes,
due to excessive fatty acid influx from adipose tissue, de novo hepatic lipogenesis, in …

[图书][B] Effects of Diet on Copper Metabolism

N Harder - 2023 - search.proquest.com
In the thesis presented here, we investigate the effects of dietary changes on copper
metabolism. With increases in incidences of metabolic diseases like non-alcoholic fatty liver …

The Correlation Between Serum Copper and Non-alcoholic Fatty Liver Disease in American Adults: an Analysis Based on NHANES 2011 to 2016

L Li, Y Yi, X Shu, J Li, H Kang, Y Chang - Biological Trace Element …, 2024 - Springer
Copper functions as an essential micronutrient influencing diverse metabolic processes in
mammals, encompassing oxidative stress responses, lipid metabolism, and participation in …

[HTML][HTML] Fatty acid uptake in liver hepatocytes induces relocalization and sequestration of intracellular copper

NHO Harder, HP Lee, VJ Flood, JA San Juan… - Frontiers in Molecular …, 2022 - frontiersin.org
Copper is an essential metal micronutrient with biological roles from energy metabolism to
cell signaling. Recent studies have shown that copper regulation is altered by fat …