The mechanism of the cadmium-induced toxicity and cellular response in the liver

V Souza-Arroyo, JJ Fabián, L Bucio-Ortiz… - Toxicology, 2022 - Elsevier
Cadmium is a toxic element to which man can be exposed at work or in the environment.
Cd's most salient toxicological property is its exceptionally long half-life in the human body …

[PDF][PDF] Liver and cadmium toxicity

VS Arroyo, KM Flores, LB Ortiz… - J Drug Metab …, 2012 - researchgate.net
Cadmium (Cd) is an important environmental pollutant. This metal presents a serious threat
for both, humans and animals health. The environmental risk can lead to the absorption of …

Role of autophagy in cadmium‐induced hepatotoxicity and liver diseases

S Niture, M Lin, Q Qi, JT Moore, KE Levine… - Journal of …, 2021 - Wiley Online Library
Cadmium (Cd) is a toxic pollutant that is associated with several severe human diseases. Cd
can be easily absorbed in significant quantities from air contamination/industrial pollution …

A rapid and transient ROS generation by cadmium triggers apoptosis via caspase-dependent pathway in HepG2 cells and this is inhibited through N-acetylcysteine …

SH Oh, SC Lim - Toxicology and applied pharmacology, 2006 - Elsevier
Although reactive oxygen species (ROS) have been implicated in cadmium (Cd)-induced
hepatotoxicity, the role of ROS in this pathway remains unclear. Therefore, we attempted to …

Time-course of cadmium-induced acute hepatotoxicity in the rat liver: the role of apoptosis

KN Tzirogiannis, GI Panoutsopoulos… - Archives of …, 2003 - Springer
Exposure to toxic metals and pollutants is a major environmental problem. Cadmium is a
metal causing acute hepatic injury but the mechanism of this phenomenon is poorly …

Cadmium and mitochondria

G Cannino, E Ferruggia, C Luparello, AM Rinaldi - Mitochondrion, 2009 - Elsevier
The heavy metal cadmium (Cd) a pollutant associated with several modern industrial
processes, is absorbed in significant quantities from cigarette smoke, water, food and air …

Cadmium-induced apoptosis in rat hepatocytes does not necessarily involve caspase-dependent pathways

TND Pham, M Marion, F Denizeau, C Jumarie - Toxicology in vitro, 2006 - Elsevier
Cadmium (Cd) is a well-known hepatotoxic environmental pollutant. Depending on the
exposure conditions, Cd may cause necrosis or apoptosis. Oxidative stress is believed to …

Long-term exposure to cadmium in food and cigarette smoke, liver effects and hepatocellular carcinoma

S Satarug - Current Drug Metabolism, 2012 - ingentaconnect.com
Rising incidence of hepatocellular carcinoma (HCC) has been noted in recent years along
with diabetes for which reasons and mechanisms are unclear. The rise in HCC is attributed …

Cadmium-induced cytotoxicity in mouse liver cells is associated with the disruption of autophagic flux via inhibiting the fusion of autophagosomes and lysosomes

H Zou, T Wang, J Yuan, J Sun, Y Yuan, J Gu, X Liu… - Toxicology Letters, 2020 - Elsevier
Cadmium (Cd) is an important environmental pollutant. Previous studies have shown that
Cd can induce liver cell injury; however, the toxicity mechanisms of Cd have not been fully …

[HTML][HTML] Cadmium-induced pathologies: where is the oxidative balance lost (or not)?

AR Nair, O DeGheselle, K Smeets… - International journal of …, 2013 - mdpi.com
Over the years, anthropogenic factors have led to cadmium (Cd) accumulation in the
environment causing various health problems in humans. Although Cd is not a Fenton-like …