The ischemically injured kidney undergoes tubular cell necrosis and apoptosis,
accompanied by an interstitial inflammatory cell infiltrate. In this study, we show that iNos …

The acutely injured mammalian kidney mounts a cellular and molecular response to repair
itself. However, in patchy regions such intrinsic processes are impaired and dysregulated …

Monocyte-derived macrophages can determine the outcome of the immune response and
whether this response contributes to tissue repair or mediates tissue destruction. In addition …

Introduction Acute kidney injury (AKI) is a major risk factor in the development of chronic
kidney disease (CKD). However, the mechanisms linking AKI to CKD remain unclear. We …

Macrophages have heterogeneous phenotypes as they exercise their twofold role in the
development and recovery of renal diseases. Some subpopulations of macrophages (M1) …

Macrophage infiltration of the kidney is a prominent feature associated with the severity of
renal injury and progressive renal failure. To determine the influence of macrophages in …

Acute kidney injury (AKI) is a growing global health concern, yet no treatment is currently
available to prevent it or to promote kidney repair after injury. Animal models demonstrate …

Background: Glomerular and interstitial macrophage infiltration is a feature for both the acute
and chronic kidney diseases. Macrophages have been shown to play a diverse role in …

Acute ischemic kidney injury is a common complication in hospitalized patients. No
treatment is yet available for augmenting kidney repair or preventing progressive kidney …

After kidney ischemia/reperfusion (I/R) injury, monocytes home to the kidney and
differentiate into activated macrophages. Whereas proinflammatory macrophages contribute …