GABAB receptors are G-protein-coupled receptors that mediate inhibitory synaptic actions
through a series of downstream target proteins. It is increasingly appreciated that the GABAB …

Ionic plasticity, a form of synaptic plasticity unique to inhibitory neurotransmission, can be
induced in cerebellar Purkinje neurons by brain-derived neurotrophic factor (BDNF). It is …

The potassium-chloride cotransporter 2 (KCC2)-dependent intracellular chloride level
determines whether neurons respond to GABA and/or glycine by depolarization or …

Key points Cation–chloride cotransporters (CCCs) play a critical role in controlling the
efficacy and polarity of GABAA receptor (GABAAR)‐mediated transmission in the brain, yet …

Hyperpolarizing synaptic inhibition through GABA A and glycine receptors depends on the
presence of the neuronal cation-chloride-cotransporter protein, KCC2. Several …

The major outward chloride transporter in neurons is the potassium chloride co-transporter 2
(KCC2), critical for maintaining an inhibitory reversal potential for GABAA receptor channels …

Key points Potassium‐chloride co‐transporter 2 (KCC2) plays a critical role in regulating
chloride homeostasis, which is essential for hyperpolarizing inhibition in the mature nervous …

Fast synaptic inhibition in the adult central nervous system (CNS) is mediated by GABA and
glycine. During early development GABA acts as an excitatory neurotransmitter, which is …

Background GABA A receptors are ligand-gated Cl-channels, and the intracellular Cl-
concentration governs whether GABA function is excitatory or inhibitory. During early brain …

Chloride (Cl−) homeostasis is critical for many cell functions including cell signaling and
volume regulation. The action of GABA at GABAA receptors is primarily determined by the …