Colon tumor cell growth–inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition
HN Tinsley, BD Gary, J Thaiparambil, N Li, W Lu… - Cancer Prevention …, 2010 - AACR
Nonsteroidal anti-inflammatory drugs (NSAID) display promising antineoplastic activity, but
toxicity resulting from cyclooxygenase (COX) inhibition limits their clinical use for …
toxicity resulting from cyclooxygenase (COX) inhibition limits their clinical use for …
A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been widely reported to inhibit tumor
growth by a COX-independent mechanism, although alternative targets have not been well …
growth by a COX-independent mechanism, although alternative targets have not been well …
New NSAID targets and derivatives for colorectal cancer chemoprevention
Clinical and preclinical studies provide strong evidence that nonsteroidal anti-inflammatory
drugs (NSAIDs) can prevent numerous types of cancers, especially colorectal cancer …
drugs (NSAIDs) can prevent numerous types of cancers, especially colorectal cancer …
Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling
Nonsteroidal anti-inflammatory drugs (NSAID) display promising antineoplastic activity for
colorectal and other cancers, but toxicity from COX inhibition limits their long-term use for …
colorectal and other cancers, but toxicity from COX inhibition limits their long-term use for …
Inhibition of colon cancer cell growth by phosphodiesterase inhibitors is independent of cGMP signaling
Y Hou, A Wren, N Mylarapu, K Browning… - … of Pharmacology and …, 2022 - ASPET
There is growing interest in the potential use of phosphodiesterase (PDE) inhibitors for
colorectal cancer (CRC) prevention and treatment. The present study has tested the idea …
colorectal cancer (CRC) prevention and treatment. The present study has tested the idea …
NSAIDs: old drugs reveal new anticancer targets
There is compelling evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) and
cyclooxygenase-2 selective inhibitors have antineoplastic activity, but toxicity from …
cyclooxygenase-2 selective inhibitors have antineoplastic activity, but toxicity from …
Growth inhibition and induction of apoptosis in colorectal tumor cells by cyclooxygenase inhibitors
M Richter, M Weiss, I Weinberger… - …, 2001 - academic.oup.com
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit colorectal carcinogenesis and
prevent or revert the growth of premalignant colonic polyps. They inhibit cyclooxygenase …
prevent or revert the growth of premalignant colonic polyps. They inhibit cyclooxygenase …
Ibuprofen inhibits activation of nuclear β-catenin in human colon adenomas and induces the phosphorylation of GSK-3β
EJ Greenspan, JP Madigan, LA Boardman… - Cancer Prevention …, 2011 - AACR
Nonselective cyclooxygenase (COX) inhibitors target many of the same cancer-associated
molecular pathways as COX-2–specific inhibitors. Although these nonsteroidal anti …
molecular pathways as COX-2–specific inhibitors. Although these nonsteroidal anti …
Sildenafil suppresses inflammation-driven colorectal cancer in mice
BN Islam, SK Sharman, Y Hou, AE Bridges… - Cancer Prevention …, 2017 - AACR
Intestinal cyclic guanosine monophosphate (cGMP) signaling regulates epithelial
homeostasis and has been implicated in the suppression of colitis and colon cancer. In this …
homeostasis and has been implicated in the suppression of colitis and colon cancer. In this …
NSAIDs activate PTEN and other phosphatases in human colon cancer cells: novel mechanism for chemopreventive action of NSAIDs
EC Chu, J Chai, AS Tarnawski - Biochemical and biophysical research …, 2004 - Elsevier
Studies on chemoprevention of colorectal cancer have generated increasing interest. The
mechanisms involved in NSAIDs chemopreventive action are not fully elucidated. In this …
mechanisms involved in NSAIDs chemopreventive action are not fully elucidated. In this …