Both T-cell deprivation and insufficient tumor immunogenicity seriously hinder the efficacy of
immune-mediated tumor destruction in melanoma. In this work, an amphiphilic polyethylene …

Ions play a vital role in regulating various biological processes, including metabolic and
immune homeostasis, which involves tumorigenesis and therapy. Thus, the perturbation of …

Immune checkpoint inhibitors have achieved significant clinical success but are still suffering
from inadequate immune activation. It is worth noting that manganese as a nutritional …

Cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) are essential
components of the innate immune sensors to cytosolic DNA and elicit type I interferon (IFN) …

As an essential micronutrient, manganese (Mn) participates in various physiological
processes and plays important roles in host immune system, hematopoiesis, endocrine …

Pyroptosis is a proinflammatory form of programmed cell death that results in the release of
cellular contents and activation of immune responses. However, GSDME (a pyroptosis …

Combination therapy that could better balance immune activation and suppressive signals
holds great potential in cancer immunotherapy. Herein, we serendipitously found that the pH …

Insufficient tumor-infiltration of the cytotoxic T lymphocytes (CTLs) and immunosuppressive
tumor microenvironment (ITM) severely hinder T cell-based cancer immunotherapy. In this …

Nanomedicine-based photodynamic therapy (PDT) for melanoma treatment has attracted
great attention. However, the complex design of polymer nanoparticles and high doses of …

Nanomaterial-based tumor photothermal therapy (PTT) has attracted increasing attention
and been a promising method for cancer treatment because of its low level of adverse …