Metabolic homeostasis in mammals is tightly regulated by the complementary actions of
insulin and glucagon. The secretion of these hormones from pancreatic β-cells and α-cells …

Endocrine cells within the pancreatic islets of Langerhans are heterogeneous in terms of
transcriptional profile, protein expression and the regulation of hormone release. Even …

Pancreatic beta cells uniquely synthetize, store, and release insulin. Specific molecular,
functional as well as ultrastructural traits characterize their insulin secretion properties and …

Pancreatic beta cells are the only cell type in our body capable of producing and secreting
insulin to instruct the insulin-sensitive cells and tissues of our bodies to absorb nutrients after …

The endocrine pancreas consists of highly vascularized and innervated endocrine mini-
organs—the islets of Langerhans. These contain multiple types of hormone-producing cells …

The appropriate function of insulin-producing pancreatic β-cells is crucial for the regulation
of glucose homeostasis, and its impairment leads to diabetes mellitus, the most common …

Insulin release from pancreatic β-cells is required to maintain normal glucose homoeostasis
in man and many other animals. Defective insulin secretion underlies all forms of diabetes …

Insulin-secreting β-cells are heterogeneous in their regulation of hormone release. While
long known, recent technological advances and new markers have allowed the identification …

Pancreatic β-cell function is essential for the regulation of glucose homeostasis and its
impairment leads to diabetes mellitus. Besides glucose, the major nutrient factor, inputs from …

In nondiabetic subjects, insulin secretion is sufficiently increased as a compensatory
adaptation to insulin resistance whereas in subjects with type 2 diabetes, the adaptation is …