In severe acute pancreatitis, multiple organ failure in the early stage after onset, and sepsis
in the late stage, due to infection of pancreatic or peripancreatic devitalized tissue, contribute …

Background: Apoptosis of hepatocytes has been reported to be involved in liver failure
complicated with systemic manifestations such as endotoxemia. We hypothesized that …

In an effort to elucidate factors that determine the severity of an attack of acute pancreatitis,
we have quantitated the extent of necrosis and of apoptosis in five different models of …

The aim of this study was to assess the significance of peritoneal macrophage in inducing
cytotoxicity in ascitic fluid associated with severe acute pancreatitis. The involvement of …

Acute pancreatitis is a disease of variable severity in which some patients experience mild,
self-limited attacks, whereas others manifest a severe, highly morbid, and frequently lethal …

BACKGROUND AND AIM: Endotoxin/bacterial translocation (E/BT) plays an important role
in systemic complications in severe acute pancreatitis (SAP). The breakdown of intestinal …

To investigate impairment of cellular immunity in severe acute pancreatitis, alterations of
peripheral lymphocytes in acute pancreatitis were examined. In 48 patients with severe …

It is generally believed that acute pancreatitis is an autodigestive disease-ie that the
pancreas is injured by digestive enzymes which are normally synthesized and secreted from …

Background: Recently renal cell apoptosis has been reported in various disorders that result
in renal failure. Thus we hypothesized that renal cell injury resulting from apoptosis is …

Context Many prior studies have suggested that the majority of deaths in severe acute
pancreatitis occur late in the course of the disease as a result of pancreatic sepsis or …