Calcification of aortic valve leaflets is a growing mortality threat for the 18 million human
lives claimed globally each year by heart disease. Extensive research has focused on the …

Calcified aortic valve disease (CAVD) is the most common heart valve disease in aged
patients, with a disease continuum that ranges from mild valve thickening to severe …

Despite recent advances, mineralization site, its microarchitecture, and composition in
calcific heart valve remain poorly understood. A multiscale investigation, using scanning …

Calcific aortic valve disease (CAVD) is the most common heart valve disorder. There is no
medical treatment to prevent and/or promote the regression of CAVD. Hence, it is of foremost …

Cardiovascular calcification can occur in vascular and valvular structures and is commonly
associated with calcium deposition and tissue mineralization leading to stiffness and …

Cardiovascular calcification is a commonly observed but incompletely understood
mechanism of increased atherosclerotic plaque instability and accelerated aortic valve …

Calcification starts with hydroxyapatite (HA) crystallization on cell membranous components,
as with aortic valve interstitial cells (AVICs), wherein a cell-membrane-derived substance …

Aims Westernized countries face a growing burden of cardiovascular calcification and
osteoporosis. Despite its vast clinical significance, the precise nature of this reciprocal …

A significant amount of knowledge has been gained with the use of cell-based assays to
elucidate the mechanisms that mediate heart valve calcification. However, cells used in …

Calcification occurs in atherosclerotic vascular lesions and in the aortic valve. Calcific aortic
valve disease (CAVD) is a slow, progressive disorder that ranges from mild valve thickening …