Brain regional synchronous activity predicts tauopathy in 3× TgAD mice
Alzheimer's disease (AD) is characterized by progressive cognitive impairment and by
extensive neuronal loss associated with extracellular amyloid β-peptide (Aβ) plaques and …
extensive neuronal loss associated with extracellular amyloid β-peptide (Aβ) plaques and …
Tau and β-amyloid are associated with medial temporal lobe structure, function, and memory encoding in normal aging
SM Marks, SN Lockhart, SL Baker… - Journal of …, 2017 - Soc Neuroscience
Normal aging is associated with a decline in episodic memory and also with aggregation of
the β-amyloid (Aβ) and tau proteins and atrophy of medial temporal lobe (MTL) structures …
the β-amyloid (Aβ) and tau proteins and atrophy of medial temporal lobe (MTL) structures …
[HTML][HTML] Tau pathology profile across a parietal-hippocampal brain network is associated with spatial reorientation learning and memory performance in the 3xTg-AD …
In early Alzheimer's disease (AD) spatial navigation is one of the first impairments to
emerge; however, the precise cause of this impairment is unclear. Previously, we showed …
emerge; however, the precise cause of this impairment is unclear. Previously, we showed …
Alzheimer's pathology is associated with dedifferentiation of intrinsic functional memory networks in aging
In presymptomatic Alzheimer's disease (AD), beta-amyloid plaques (Aβ) and tau tangles
accumulate in distinct spatiotemporal patterns within the brain, tracking closely with episodic …
accumulate in distinct spatiotemporal patterns within the brain, tracking closely with episodic …
[HTML][HTML] Tau pathology in early Alzheimer's disease is linked to selective disruptions in neurophysiological network dynamics
Understanding the role of Tau protein aggregation in the pathogenesis of Alzheimer's
disease is critical for the development of new Tau-based therapeutic strategies to slow or …
disease is critical for the development of new Tau-based therapeutic strategies to slow or …
Temporal and regional progression of Alzheimer's disease‐like pathology in 3xTg‐AD mice
R Belfiore, A Rodin, E Ferreira, R Velazquez… - Aging cell, 2019 - Wiley Online Library
Accumulation of amyloid‐β (Aβ) and fibrillary tangles, as well as neuroinflammation and
memory loss, are hallmarks of Alzheimer's disease (AD). After almost 15 years from their …
memory loss, are hallmarks of Alzheimer's disease (AD). After almost 15 years from their …
[HTML][HTML] Localized APP expression results in progressive network dysfunction by disorganizing spike timing
Progressive cognitive decline in Alzheimer's disease could either be caused by a spreading
molecular pathology or by an initially focal pathology that causes aberrant neuronal activity …
molecular pathology or by an initially focal pathology that causes aberrant neuronal activity …
Altered excitatory and inhibitory neuronal subpopulation parameters are distinctly associated with tau and amyloid in Alzheimer's disease
Background: Neuronal-and circuit-level abnormalities of excitation and inhibition are shown
to be associated with tau and amyloid-beta (Aβ) in preclinical models of Alzheimer's disease …
to be associated with tau and amyloid-beta (Aβ) in preclinical models of Alzheimer's disease …
Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease
JS Jacobsen, CC Wu, JM Redwine… - Proceedings of the …, 2006 - National Acad Sciences
Alzheimer's disease (AD) is a progressive neurodegenerative disorder for which numerous
mouse models have been generated. In both AD patients and mouse models, there is …
mouse models have been generated. In both AD patients and mouse models, there is …
Alzheimer's pathology targets distinct memory networks in the ageing brain
Alzheimer's disease researchers have been intrigued by the selective regional vulnerability
of the brain to amyloid-β plaques and tau neurofibrillary tangles. Post-mortem studies …
of the brain to amyloid-β plaques and tau neurofibrillary tangles. Post-mortem studies …