The efficacy of donepezil administration on acetylcholinesterase activity and altered redox homeostasis in Alzheimer's disease

P Atukeren, M Cengiz, H Yavuzer, R Gelisgen… - Biomedicine & …, 2017 - Elsevier
Alzheimer's disease (AD) is a serious multifactorial disorder with progressive
neurodegenerative outcomes related with impaired redox homeostasis. Inhibition of the …

Does caffeine influence the anticholinesterase and antioxidant properties of donepezil? Evidence from in vitro and in vivo studies

G Oboh, OB Ogunsuyi, OE Olonisola - Metabolic brain disease, 2017 - Springer
Caffeine is adjudged world's most consumed pharmacologically active food component.
With reports of the potential cognitive enhancing properties of caffeine, we sought to …

[PDF][PDF] Evaluation of the antioxidant activity of donepezil-in vitro study

V Munishamappa, VA Seethalakshmi… - Nat J Physiol Pharm …, 2019 - njppp.com
Background: Donepezil is a cerebroselective anticholinesterase which is majorly used for
memory enhancement in Alzheimer's disease (AD). The main action is through increasing …

Clinical profile of donepezil in the treatment of Alzheimer's disease

RS Doody - Gerontology, 1999 - karger.com
Although the underlying pathogenesis of Alzheimer's disease (AD) is not fully understood,
one of its key features is the widespread loss of central cholinergic innervation, known to be …

Perspectives in the management of Alzheimer's disease: clinical profile of donepezil

SL Rogers - Dementia and geriatric cognitive disorders, 1998 - karger.com
Donepezil HCl is a piperidine-based reversible acetylcholinesterase (AChE) inhibitor,
chemically distinct from other cholinesterase (ChE) inhibitors and rationally designed to treat …

Donepezil in the treatment of patients with Alzheimer's disease

N Tsuno - Expert review of neurotherapeutics, 2009 - Taylor & Francis
Alzheimer's disease (AD) is the most common cause of dementia and is characterized by an
insidious onset and slow deterioration in cognition, activities of daily living (ADL), mood …

Effects of donepezil on liver and kidney functions for the treatment of Alzheimer's disease

Z Erbayraktar, A Evlice, G Yener… - Journal of integrative …, 2017 - content.iospress.com
Aim of the present study is to investigate the effects of medication with donepezil
(acetylcholinesterase inhibitor) on the liver and kidney function in Alzheimer's disease (AD) …

Inhibitory effects of donepezil hydrochloride (E2020) on cholinesterase activity in brain and peripheral tissues of young and aged rats

T Kosasa, Y Kuriya, K Matsui, Y Yamanishi - European journal of …, 1999 - Elsevier
Donepezil hydrochloride (donepezil: E2020:(±)-2-[(1-benzylpiperidin-4-yl) methyl]-5, 6-
dimethoxy-indan-1-one monohydrochloride)) is a centrally acting acetylcholinesterase …

Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors

H Sugimoto, Y Yamanish, Y Iimura… - Current medicinal …, 2000 - ingentaconnect.com
A wide range of evidence shows that acetylcholinesterase (AChE) inhibitors can interfere
with the progression of Alzheimer disease (AD). The successful development of these …

A systematic review on donepezil-based derivatives as potential cholinesterase inhibitors for Alzheimer's disease

J Korabecny, K Spilovska, E Mezeiova… - Current Medicinal …, 2019 - ingentaconnect.com
Alzheimer's Disease (AD) is a multifactorial progressive neurodegenerative disorder
characterized by memory loss, disorientation, and gradual deterioration of intellectual …