Cisplatin is a widely used chemotherapeutic agent for the treatment of various tumors, but its
side effects limit its application. Ototoxicity, a major adverse effect of cisplatin, causes …

Cisplatin is an antitumor drug that is widely used for the treatment of various solid tumors.
Unfortunately, patients are often troubled by serious side effects, especially hearing loss. Up …

Cisplatin-induced ototoxicity is one of the major adverse effects in cisplatin chemotherapy,
and hearing protective approaches are unavailable in clinical practice. Recent work …

Cisplatin-induced hearing loss is a common side effect of cisplatin chemotherapy, for which
clinical therapy remains unavailable. Apoptosis of hair cells is considered the primary cause …

Aims FAM134B, the initial endoplasmic reticulum (ER)-phagy receptor identified, facilitates
ER-phagy during ER stress. The malfunction of FAM134B has been demonstrated to have a …

Cisplatin-induced hearing loss is a common side effect of cancer chemotherapy in clinics;
however, the mechanism of cisplatin-induced ototoxicity is still not completely clarified …

Objective Hearing loss is a major side effect of cisplatin chemotherapy. Although cell death
in cisplatin-induced ototoxicity is primarily caused by apoptosis, the exact mechanism …

Cisplatin is widely used in clinical tumor chemotherapy but has severe ototoxic side effects,
including tinnitus and hearing damage. This study aimed to determine the molecular …

Aims: Cisplatin, an anticancer drug, always leads to nephrotoxicity by causing mitochondrial
dysfunction. As a major mechanism for cellular self-degradation, autophagy has been …

Hearing loss is the most common sensory disorder in humans, and a significant number of
cases is due to the ototoxicity of drugs such as cisplatin that cause hair cell (HC) damage …