Screening anti‐anaphylactoid components in Polygonum cuspidatum via cell membrane chromatography with LC‐MS targeting Mas‐related G protein‐coupled …

Y Lin, H Lu, Q Jia, S Han - Journal of Separation Science, 2024 - Wiley Online Library
Mas‐related G protein‐coupled receptor X2 (MrgprX2) is acknowledged as a mast cell‐
specific receptor, playing a crucial role in orchestrating anaphylactoid responses through …

Cell membrane chromatography coupled online with LC‐MS to screen anti‐anaphylactoid components from Magnolia biondii Pamp. targeting on Mas‐related G …

Y Lin, J Xu, Q Jia, W Sun, J Fu, Y Lv… - Journal of Separation …, 2020 - Wiley Online Library
Mas‐related G protein‐coupled receptor X2 was a mast cell–specific receptor mediating
anaphylactoid reactions by activating mast cells degranulation, and it was also identified as …

The anti‐anaphylactoid effects of Piperine through regulating MAS‐related G protein‐coupled receptor X2 activation

C Qiao, S Hu, D Che, J Wang, J Gao, R Ma… - Phytotherapy …, 2020 - Wiley Online Library
Mast cells play an important role in inflammatory and allergic diseases. MAS‐related G
protein‐coupled receptor X2 (MRGPRX2) is a novel G protein‐coupled receptor in mast …

Dehydroandrographolide targets CD300f and negatively regulated MRGPRX2‐induced pseudo‐allergic reaction

D Che, Y Zheng, Y Hou, T Li, X Du… - Phytotherapy …, 2022 - Wiley Online Library
Mas‐related G protein‐coupled receptor X2 (MRGPRX2) mediates mast cells (MCs)
activation, which is a key target for the treatment of allergic diseases. However, there are few …

Myricetin served as antagonist for negatively regulate MRGPRX2 mediated pseudo-allergic reactions through CD300f/SHP1/SHP2 phosphorylation

B Dang, S Hu, Y Zhang, Y Huang, T Zhang… - International …, 2023 - Elsevier
Background Mas-related G protein-coupled receptor X2 (MRGPRX2) plays a vital role in
mast cells (MCs) degranulation and pseudo-allergic reactions. Leukocyte mono …

Inhibitory function of Shikonin on MRGPRX2-mediated pseudo-allergic reactions induced by the secretagogue

J Wang, Y Zhang, C Li, Y Ding, S Hu, H An - Phytomedicine, 2020 - Elsevier
Abstract Background Mast cells (MCs) are crucial effectors in allergic disorders by secreting
inflammatory mediators. The Mas-related G-protein-coupled receptor X2 (Mrgprx2) was …

Osthole, a natural plant derivative inhibits MRGPRX2 induced mast cell responses

BN Callahan, AK Kammala, M Syed, C Yang… - Frontiers in …, 2020 - frontiersin.org
Mast cells are tissue-resident innate immune cells known for their prominent role in
mediating allergic reactions. MAS-related G-protein coupled receptor-X2 (MRGPRX2) is a …

MrgX2-targeted ligand screening from Artemisia capillaris Thunb. extract and receptor-ligand interaction analysis based on MrgX2-HALO-tag/CMC

Y Jiang, N Guo, Q Zhang, X Xu, M Qiang… - Journal of Chromatography …, 2024 - Elsevier
Artemisia capillaris Thunb.(A. capillaris) is a well-known traditional Chinese herbal medicine
with a wide range of pharmacological effects, such as soothing the liver and gallbladder …

Paeoniflorin inhibits MRGPRX2‐mediated pseudo‐allergic reaction via calcium signaling pathway

J Wang, Y Zhang, J Wang, R Liu, G Zhang… - Phytotherapy …, 2020 - Wiley Online Library
Mas‐related G protein‐coupled receptor‐X2 (MRGPRX2) expressed on mast cells (MCs)
has been shown to be a pivotal target for pseudo‐allergic diseases. Therefore, MRGPRX2 …

Polymyxin B and polymyxin E induce anaphylactoid response through mediation of Mas-related G protein–coupled receptor X2

Y Zhan, N Ma, R Liu, N Wang, T Zhang, L He - Chemico-biological …, 2019 - Elsevier
Polymyxin B (PMB) and polymyxin E (PME) are cyclic, peptide antibiotics which derived from
various species of Paenibacillus (Bacillus) polymyxa. They are decapeptide antibiotics with …