Metal assisted peptide bond hydrolysis: Chemistry, biotechnology and toxicological implications

NE Wezynfeld, T Frączyk, W Bal - Coordination Chemistry Reviews, 2016 - Elsevier
Metal-assisted hydrolysis of peptide bond is a promising alternative for enzymatic cleavage
of proteins with prospective applications in biochemistry and bioengineering. Many metal …

Major advances in the hydrolysis of peptides and proteins by metal ions and complexes

KB Grant, M Kassai - Current Organic Chemistry, 2006 - ingentaconnect.com
Metal ions and complexes that hydrolyze peptides and proteins have become increasingly
important in recent years. These reagents have shown great promise for use in a variety of …

Peptide-or protein-cleaving agents based on metal complexes

WS Chei, J Suh - Progress in inorganic chemistry, 2008 - books.google.com
Catalysis by metal ions in organic reactions is classified into three categories: Lewis acid
catalysis, catalysis via redox reactions, and catalysis via organometallic compounds (1) …

Lanthanide ion-mediated peptide hydrolysis

M Komiyama - Metal Ions in Biological Systems, 2001 - books.google.com
Artificial peptidases are valuable tools for future biotechnology, and their preparation has
constituted a highly challenging task for chemists. If naturally occurring proteins can be cut at …

Hydrolysis of amide bond in histidine-containing peptides promoted by chelated amino acid palladium (II) complexes: dependence of hydrolytic pathway on the …

MI Djuran, SU Milinković - Polyhedron, 1999 - Elsevier
Hydrolytic reactions between cis-[Pd (l-Ala-N, O) Cl2]− and cis-[Pd (l-Ala-N, O)(H2O) 2]+, in
which l-Ala is alanine coordinated through N and O atoms, and N-acetylated peptides l …

Sequence-specific Ni (II)-dependent peptide bond hydrolysis for protein engineering: Active sequence optimization

AM Protas, HHN Ariani, A Bonna… - Journal of inorganic …, 2013 - Elsevier
In previous studies we showed that Ni (II) ions can hydrolytically cleave a peptide bond
preceding Ser/Thr in peptides of a general sequence RN–(Ser/Thr)–Xaa–His–Zaa–RC …

Sequence-specific Ni (II)-dependent peptide bond hydrolysis for protein engineering: reaction conditions and molecular mechanism

E Kopera, A Krezel, AM Protas, A Belczyk… - Inorganic …, 2010 - ACS Publications
Recently we screened a combinatorial library of R1-(Ser/Thr)-Xaa-His-Zaa-R2 peptides
(Xaa= 17 common α-amino acids, except Asp, Glu, and Cys; Zaa= 19 common α-amino …

Metal-ion-assisted hydrolysis of dipeptides involving a serine residue in a neutral aqueous solution

M Yashiro, Y Sonobe, A Yamamura… - Organic & …, 2003 - pubs.rsc.org
Dipeptides having a serine residue at the C-terminus, X-Ser, where X is an appropriate
amino acid residue, were efficiently hydrolyzed in the presence of ZnCl2 at pH 7.0. The rapid …

New selectivity and turnover in peptide hydrolysis by metal complexes. A palladium (II) aqua complex catalyzes cleavage of peptides next to the histidine residue

TN Parac, NM Kostić - Journal of the American Chemical Society, 1996 - ACS Publications
This seems to be the first report that a transition-metal complex bonded to a histidine residue
effects hydrolytic cleavage of a peptide next to this residue. Dipeptides AcHis-Aa in which …

Effect of d-Amino Acid Substitutions on Ni(II)-Assisted Peptide Bond Hydrolysis

HH Ariani, A Polkowska-Nowakowska… - Inorganic Chemistry, 2013 - ACS Publications
Previously we demonstrated the sequence-specific hydrolysis of the R1-(Ser/Thr)-peptide
bond in Ni (II) complexes of peptides with a general R1-(Ser/Thr)-Xaa-His-Zaa-R2 sequence …