LAMP-1 chimeric to HIV-1 p55Gag in the immunization of neonate mice induces an early germinal center formation and AID expression
FME Teixeira, LM Oliveira, AJ Pietrobon, ÉM Salles… - Vaccines, 2022 - mdpi.com
Neonates have a limited adaptive response of plasma cells, germinal center (GC) B cells,
and T follicular helper cells (TFH). As neonatal vaccination can be an important tool for AIDS …
and T follicular helper cells (TFH). As neonatal vaccination can be an important tool for AIDS …
[HTML][HTML] Immunization of neonatal mice with LAMP/p55 HIV gag DNA elicits robust immune responses that last to adulthood
PO Rigato, M Maciel Jr, AL Goldoni, O Piubelli… - Virology, 2010 - Elsevier
Successful T cell priming in early postnatal life that can generate effective long-lasting
responses until adulthood is critical in HIV vaccination strategies because it prevents early …
responses until adulthood is critical in HIV vaccination strategies because it prevents early …
Maternal LAMP/p55gagHIV-1 DNA Immunization Induces In Utero Priming and a Long-Lasting Immune Response in Vaccinated Neonates
PO Rigato, M Maciel Jr, AL Goldoni, OG Piubelli… - PLoS …, 2012 - journals.plos.org
Infants born to HIV-infected mothers are at high risk of becoming infected during gestation or
the breastfeeding period. A search is thus warranted for vaccine formulations that will …
the breastfeeding period. A search is thus warranted for vaccine formulations that will …
Mucosal and systemic anti-GAG immunity induced by neonatal immunization with HIV LAMP/gag DNA vaccine in mice
AL Goldoni, M Maciel Jr, PO Rigato, O Piubelli… - Immunobiology, 2011 - Elsevier
Vaccines capable of inducing mucosal immunity in early postnatal life until adulthood,
protecting early sexual initiation, should be considered as strategies to vaccination against …
protecting early sexual initiation, should be considered as strategies to vaccination against …
Regulation of HIV-Gag expression and targeting to the endolysosomal/secretory pathway by the luminal domain of lysosomal-associated membrane protein (LAMP-1) …
We have previously demonstrated that a DNA vaccine encoding HIV-p55 gag in association
with the lysosomal associated membrane protein-1 (LAMP-1) elicited a greater Gag-specific …
with the lysosomal associated membrane protein-1 (LAMP-1) elicited a greater Gag-specific …
Dendritic cells primed with a chimeric plasmid containing HIV‐1‐gag associated with lysosomal‐associated protein‐1 (LAMP/gag) is a potential therapeutic vaccine …
CGDO Lucas, FL Matassoli, LMT Peçanha… - The FASEB …, 2016 - Wiley Online Library
The decline in number and function of T cells is a hallmark of HIV infection, and preservation
or restoration of HIV‐specific cellular immune response is a major goal of AIDS treatment …
or restoration of HIV‐specific cellular immune response is a major goal of AIDS treatment …
HIV-1 p55Gag encoded in the lysosome-associated membrane protein-1 as a DNA plasmid vaccine chimera is highly expressed, traffics to the major histocompatibility …
ETA Marques, P Chikhlikar, LB De Arruda… - Journal of Biological …, 2003 - ASBMB
Several genetic vaccines encoding antigen chimeras containing the lysosome-associated
membrane protein (LAMP) translocon, transmembrane, and cytoplasmic domain sequences …
membrane protein (LAMP) translocon, transmembrane, and cytoplasmic domain sequences …
Dendritic cell-lysosomal-associated membrane protein (LAMP) and LAMP-1-HIV-1 gag chimeras have distinct cellular trafficking pathways and prime T and B cell …
LB Arruda, D Sim, PR Chikhlikar, M Maciel… - The Journal of …, 2006 - journals.aai.org
Ag processing is a critical step in defining the repertoire of epitope-specific immune
responses. In the present study, HIV-1 p55Gag Ag was synthesized as a DNA plasmid with …
responses. In the present study, HIV-1 p55Gag Ag was synthesized as a DNA plasmid with …
Dendritic cell mediated delivery of plasmid DNA encoding LAMP/HIV-1 Gag fusion immunogen enhances T cell epitope responses in HLA DR4 transgenic mice
GG Simon, Y Hu, AM Khan, J Zhou, J Salmon… - PloS one, 2010 - journals.plos.org
This report describes the identification and bioinformatics analysis of HLA-DR4-restricted
HIV-1 Gag epitope peptides, and the application of dendritic cell mediated immunization of …
HIV-1 Gag epitope peptides, and the application of dendritic cell mediated immunization of …
DNA encoding an HIV-1 Gag/human lysosome-associated membrane protein-1 chimera elicits a broad cellular and humoral immune response in Rhesus macaques
P Chikhlikar, LB de Arruda, M Maciel, P Silvera… - PloS one, 2006 - journals.plos.org
Previous studies of HIV-1 p55Gag immunization of mice have demonstrated the usefulness
of targeting antigens to the cellular compartment containing the major histocompatibility …
of targeting antigens to the cellular compartment containing the major histocompatibility …