Current and emerging gonadotropin-releasing hormone (GnRH) antagonists for the treatment of prostate cancer

M Moussa, A Papatsoris, A Dellis… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: Androgen deprivation therapy (ADT) is currently the backbone treatment of
metastatic prostate cancer and is also used in combination with external beam radiotherapy …

Relugolix, an oral gonadotropin-releasing hormone antagonist for the treatment of prostate cancer

DJ George, DP Dearnaley - Future Oncology, 2021 - Taylor & Francis
Androgen deprivation therapy using gonadotropin-releasing hormone (GnRH) analogues is
standard treatment for intermediate and advanced prostate cancer. GnRH agonist therapy …

Relugolix: a novel androgen deprivation therapy for management of patients with advanced prostate cancer

F Saad, ND Shore - Therapeutic Advances in Medical …, 2021 - journals.sagepub.com
Androgen deprivation therapy (ADT) is the foundation of treatment for patients with locally
advanced, recurrent and metastatic prostate cancer, most commonly using luteinizing …

The cardiovascular effects of gonadotropin-releasing hormone antagonists in men with prostate cancer

F Cirne, N Aghel, JA Petropoulos, L Klotz… - European Heart …, 2022 - academic.oup.com
Aims The aim of this study was to determine whether gonadotropin-releasing hormone
(GnRH) antagonists (an emerging class of drugs to suppress testosterone synthesis in the …

Relugolix in the management of prostate cancer

KK Sahu, N Tripathi, N Agarwal… - Expert Review of …, 2022 - Taylor & Francis
Introduction Relugolix is the first oral gonadotrophin-releasing hormone (GnRH) receptor
antagonist. Based on the phase III HERO trial results, relugolix received Food and Drug …

[HTML][HTML] Relugolix as a promising novel oral GnRH antagonist for prostate cancer treatment

J Lv, J Lin - Asian Journal of Andrology, 2021 - journals.lww.com
Open Access site reaction, the requirement of monthly administration, and the less profit in
practice. To seek an oral alternative seems very reasonable. Oral medicine is one of the …

[HTML][HTML] The role of gonadotrophin-releasing hormone antagonists in the treatment of patients with advanced hormone-dependent prostate cancer in the UK

DJ Rosario, P Davey, J Green, D Greene… - World journal of …, 2016 - Springer
Purpose Comparing gonadotrophin-releasing hormone (GnRH) antagonists and agonists as
androgen deprivation therapy for advanced prostate cancer (PC). Methods This article stems …

Gonadotropin-releasing hormone antagonists versus standard androgen suppression therapy for advanced prostate cancer A systematic review with meta-analysis

F Kunath, H Borgmann, A Blümle, B Keck, B Wullich… - BMJ open, 2015 - bmjopen.bmj.com
Objectives To evaluate efficacy and safety of gonadotropin-releasing hormone (GnRH)
antagonists compared to standard androgen suppression therapy for advanced prostate …

Progress in clinical research on gonadotropin-releasing hormone receptor antagonists for the treatment of prostate cancer

YF Liu, SQ Fu, YC Yan, BB Gong, WJ Xie… - Drug Design …, 2021 - Taylor & Francis
Gonadotropin-releasing hormone (GnRH) receptor agonists are still the most commonly
used androgen deprivation treatment (ADT) drugs for prostate cancer in clinical practice …

Differential impact of gonadotropin-releasing hormone antagonist versus agonist on clinical safety and oncologic outcomes on patients with metastatic prostate cancer …

M Abufaraj, T Iwata, S Kimura, A Haddad, H Al-Ani… - European Urology, 2021 - Elsevier
Context Androgen deprivation therapy is the mainstay treatment of metastatic prostate
cancer, achieved mainly by gonadotropin-releasing hormone (GnRH) agonists or …