Animal models and mechanisms of tobacco smoke-induced chronic obstructive pulmonary disease (COPD)

P Upadhyay, CW Wu, A Pham, AA Zeki… - Journal of Toxicology …, 2023 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death
worldwide, and its global health burden is increasing. COPD is characterized by …

Tobacco smoke induced COPD/emphysema in the animal model—are we all on the same page?

M Leberl, A Kratzer, L Taraseviciene-Stewart - Frontiers in physiology, 2013 - frontiersin.org
Chronic Obstructive Pulmonary Disease (COPD) is one of the foremost causes of death
worldwide. It is primarily caused by tobacco smoke, making it an easily preventable disease …

Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease

T Yoshida, RM Tuder - Physiological reviews, 2007 - journals.physiology.org
Chronic obstructive pulmonary diseases (COPD), comprised of pulmonary emphysema,
chronic bronchitis, and structural and inflammatory changes of small airways, is a leading …

Animal models of cigarette smoke-induced chronic obstructive pulmonary disease

JL Wright, A Churg - Expert review of respiratory medicine, 2010 - Taylor & Francis
Chronic exposure of laboratory animals to cigarette smoke reproduces many of the
anatomic/physiologic lesions (emphysema, small-airway remodeling and pulmonary …

Preclinical murine models of chronic obstructive pulmonary disease

R Vlahos, S Bozinovski - European journal of pharmacology, 2015 - Elsevier
Abstract Chronic Obstructive Pulmonary Disease (COPD) is a major incurable global health
burden and is the 4th leading cause of death worldwide. It is believed that an exaggerated …

Animal models of chronic obstructive pulmonary disease

M Fricker, A Deane, PM Hansbro - Expert opinion on drug …, 2014 - Taylor & Francis
Introduction: Chronic obstructive pulmonary disease (COPD) is a leading global cause of
mortality and chronic morbidity. Inhalation of cigarette smoke is the principal risk factor for …

Understanding the relevance of the mouse cigarette smoke model of COPD: peering through the smoke

RW Vandivier, M Ghosh - American Journal of Respiratory Cell and …, 2017 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is one of the most important threats to public
health because of its prevalence, economic cost, and impact on death and disability …

Animal models of cigarette smoke-induced COPD

JL Wright, A Churg - Chest, 2002 - Elsevier
Objectives To review the animal models of COPD, and to compare these data to those found
in humans. Results Smoke-induced animal models can produce emphysema, although the …

Integrative characterization of chronic cigarette smoke-induced cardiopulmonary comorbidities in a mouse model

Á Kemény, I Szitter, ZV Varga, P Bencsik, K Kiss… - Environmental …, 2017 - Elsevier
Cigarette smoke-triggered inflammatory cascades and consequent tissue damage are the
main causes of chronic obstructive pulmonary disease (COPD). There is no effective therapy …

Models for COPD involving cigarette smoke

PA Martorana, E Cavarra, M Lucattelli… - Drug Discovery Today …, 2006 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a major cause of chronic morbidity and
mortality throughout the world. Its impact has resulted in dynamic research into the …