Mechanisms of vertebrate DNA interstrand cross-link repair
DNA interstrand cross-links (ICLs) covalently connect the two strands of the double helix and
are extremely cytotoxic. Defective ICL repair causes the bone marrow failure and cancer …
are extremely cytotoxic. Defective ICL repair causes the bone marrow failure and cancer …
Advances in understanding the complex mechanisms of DNA interstrand cross-link repair
C Clauson, OD Schärer… - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
DNA interstrand cross-links (ICLs) are lesions caused by a variety of endogenous
metabolites, environmental exposures, and cancer chemotherapeutic agents that have two …
metabolites, environmental exposures, and cancer chemotherapeutic agents that have two …
[HTML][HTML] DNA crosslinking damage and cancer-a tale of friend and foe
Y Huang, L Li - Translational cancer research, 2013 - ncbi.nlm.nih.gov
Interstrand crosslinks (ICLs) represent a major challenge for DNA replication and
transcription by preventing DNA strand separation. Cells deficient in ICL repair are …
transcription by preventing DNA strand separation. Cells deficient in ICL repair are …
DNA interstrand crosslink repair and cancer
Interstrand crosslinks (ICLs) are highly toxic DNA lesions that prevent transcription and
replication by inhibiting DNA strand separation. Agents that induce ICLs were one of the …
replication by inhibiting DNA strand separation. Agents that induce ICLs were one of the …
Repair of DNA interstrand cross-links
MLG Dronkert, R Kanaar - Mutation Research/DNA Repair, 2001 - Elsevier
DNA interstrand cross-links (ICLs) are very toxic to dividing cells, because they induce
mutations, chromosomal rearrangements and cell death. Inducers of ICLs are important …
mutations, chromosomal rearrangements and cell death. Inducers of ICLs are important …
DNA interstrand cross-link repair requires replication-fork convergence
DNA interstrand cross-links (ICLs) prevent strand separation during DNA replication and
transcription and therefore are extremely cytotoxic. In metazoans, a major pathway of ICL …
transcription and therefore are extremely cytotoxic. In metazoans, a major pathway of ICL …
Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathway
A Rothfuss, M Grompe - Molecular and cellular biology, 2004 - Taylor & Francis
The detailed mechanisms of DNA interstrand cross-link (ICL) repair and the involvement of
the Fanconi anemia (FA)/BRCA pathway in this process are not known. Present models …
the Fanconi anemia (FA)/BRCA pathway in this process are not known. Present models …
Using synthetic DNA interstrand crosslinks to elucidate repair pathways and identify new therapeutic targets for cancer chemotherapy
A Guainazzi, OD Schärer - Cellular and molecular life sciences, 2010 - Springer
Many cancer chemotherapeutic agents form DNA interstrand crosslinks (ICLs), extremely
cytotoxic lesions that form covalent bonds between two opposing DNA strands, blocking …
cytotoxic lesions that form covalent bonds between two opposing DNA strands, blocking …
XPF-ERCC1 acts in Unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP/SLX4
DK Douwel, RACM Boonen, DT Long, AA Szypowska… - Molecular cell, 2014 - cell.com
DNA interstrand crosslinks (ICLs), highly toxic lesions that covalently link the Watson and
Crick strands of the double helix, are repaired by a complex, replication-coupled pathway in …
Crick strands of the double helix, are repaired by a complex, replication-coupled pathway in …
XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair
Interstrand cross-links (ICLs) prevent DNA strand separation and, therefore, transcription
and replication, making them extremely cytotoxic. The precise mechanism by which ICLs are …
and replication, making them extremely cytotoxic. The precise mechanism by which ICLs are …