[HTML][HTML] B cell memory: building two walls of protection against pathogens
Surviving a single infection often results in lifelong immunity to the infecting pathogen. Such
protection is mediated, in large part, by two main B cell memory 'walls'—namely, long-lived …
protection is mediated, in large part, by two main B cell memory 'walls'—namely, long-lived …
Memory B cells
T Inoue, T Kurosaki - Nature Reviews Immunology, 2024 - nature.com
Recent advances in studies of immune memory in mice and humans have reinforced the
concept that memory B cells play a critical role in protection against repeated infections …
concept that memory B cells play a critical role in protection against repeated infections …
[HTML][HTML] Plasma cell survival in the absence of B cell memory
E Hammarlund, A Thomas, IJ Amanna… - Nature …, 2017 - nature.com
Pre-existing serum antibodies play an important role in vaccine-mediated protection against
infection but the underlying mechanisms of immune memory are unclear. Clinical studies …
infection but the underlying mechanisms of immune memory are unclear. Clinical studies …
[HTML][HTML] Generation of high quality memory B cells
T Inoue, R Shinnakasu, T Kurosaki - Frontiers in immunology, 2022 - frontiersin.org
Protection against pathogen re-infection is mediated, in large part, by two humoral cellular
compartments, namely, long-lived plasma cells and memory B cells. Recent data have …
compartments, namely, long-lived plasma cells and memory B cells. Recent data have …
[HTML][HTML] Remembrance of things past: long-term B cell memory after infection and vaccination
AKE Palm, C Henry - Frontiers in immunology, 2019 - frontiersin.org
The success of vaccines is dependent on the generation and maintenance of immunological
memory. The immune system can remember previously encountered pathogens, and …
memory. The immune system can remember previously encountered pathogens, and …
Memory B and memory plasma cells
Vaccination provides a powerful means to control infections. It exploits and exemplifies the
ability of the immune system to preserve the information that a specific pathogen has been …
ability of the immune system to preserve the information that a specific pathogen has been …
Heterogeneity in the differentiation and function of memory B cells
JJ Taylor, MK Jenkins, KA Pape - Trends in immunology, 2012 - cell.com
Vaccines that induce neutralizing antibodies have led to the eradication of small pox and
have severely reduced the prevalence of many other infections. However, even the most …
have severely reduced the prevalence of many other infections. However, even the most …
Generation of memory B cells and their reactivation
T Inoue, I Moran, R Shinnakasu, TG Phan… - Immunological …, 2018 - Wiley Online Library
The successful establishment of humoral memory response depends on at least two layers
of defense. Pre‐existing protective antibodies secreted by long‐lived plasma cells act as a …
of defense. Pre‐existing protective antibodies secreted by long‐lived plasma cells act as a …
Human B cell memory
A Lanzavecchia, F Sallusto - Current opinion in immunology, 2009 - Elsevier
Following an immune response two types of differentiated B cells persist in the memory pool:
plasma cells, which confer immediate protection by the secretion of specific antibodies; and …
plasma cells, which confer immediate protection by the secretion of specific antibodies; and …
[HTML][HTML] Plasmodium-specific atypical memory B cells are short-lived activated B cells
D Perez-Mazliah, PJ Gardner, E Schweighoffer… - Elife, 2018 - elifesciences.org
A subset of atypical memory B cells accumulates in malaria and several infections,
autoimmune disorders and aging in both humans and mice. It has been suggested these …
autoimmune disorders and aging in both humans and mice. It has been suggested these …