Surviving a single infection often results in lifelong immunity to the infecting pathogen. Such
protection is mediated, in large part, by two main B cell memory 'walls'—namely, long-lived …

Recent advances in studies of immune memory in mice and humans have reinforced the
concept that memory B cells play a critical role in protection against repeated infections …

Pre-existing serum antibodies play an important role in vaccine-mediated protection against
infection but the underlying mechanisms of immune memory are unclear. Clinical studies …

Protection against pathogen re-infection is mediated, in large part, by two humoral cellular
compartments, namely, long-lived plasma cells and memory B cells. Recent data have …

The success of vaccines is dependent on the generation and maintenance of immunological
memory. The immune system can remember previously encountered pathogens, and …

Vaccination provides a powerful means to control infections. It exploits and exemplifies the
ability of the immune system to preserve the information that a specific pathogen has been …

Vaccines that induce neutralizing antibodies have led to the eradication of small pox and
have severely reduced the prevalence of many other infections. However, even the most …

The successful establishment of humoral memory response depends on at least two layers
of defense. Pre‐existing protective antibodies secreted by long‐lived plasma cells act as a …

Following an immune response two types of differentiated B cells persist in the memory pool:
plasma cells, which confer immediate protection by the secretion of specific antibodies; and …

A subset of atypical memory B cells accumulates in malaria and several infections,
autoimmune disorders and aging in both humans and mice. It has been suggested these …