Acute stress puts cells at risk, and rapid adaptation is crucial for maximizing cell survival.
Cellular adaptation mechanisms include modification of certain aspects of cell physiology …

Organisms are constantly exposed to a wide range of environmental changes, including
both short-term changes during their lifetime and longer-term changes across generations …

Cells adjust their transcriptional state to accommodate environmental and genetic
perturbations. An open question is to what extent transcriptional response to perturbations …

The state of the transcriptome reflects a balance between mRNA production and
degradation. Yet how these two regulatory arms interact in shaping the kinetics of the …

Adaptation is essential for maximizing cell survival and for cell fitness in response to sudden
changes in the environment. Several aspects of cell physiology change during adaptation …

Programs of gene expression are executed by a battery of transcription factors that
coordinate divergent transcription from a pair of tightly linked core initiation regions of …

Organisms mount the cellular stress response whenever environmental parameters exceed
the range that is conducive to maintaining homeostasis. This response is critical for survival …

Background Stresses exert evolutionary pressures on all organisms, which have developed
sophisticated responses to cope and survive. These responses involve cellular physiology …

Yeast cells respond to stress by mediating condition-specific gene expression changes and
by mounting a common response to many stresses, called the environmental stress …

Global analysis of mRNA abundance via genomic arrays (ie transcriptomics or
transcriptional profiling) is one approach to finding the genes that matter to organisms …