Increasing global concerns of pandemic respiratory viruses highlight the importance of
developing optimal vaccination strategies that encompass vaccine platform, delivery route …

The world is in need of next-generation COVID-19 vaccines. Although first-generation
injectable COVID-19 vaccines continue to be critical tools in controlling the current global …

Inducing humoral and cytotoxic mucosal immunity at the sites of pathogen entry has the
potential to prevent the infection from getting established. This is different from systemic …

Viruses that replicate in the human respiratory mucosa without infecting systemically,
including influenza A, SARS-CoV-2, endemic coronaviruses, RSV, and many other" …

Infectious diseases of the respiratory tract are one of the top causes of global morbidity and
mortality with lower respiratory tract infections being the fourth leading cause of death. The …

Background Adenovirus-vectored (Ad-vectored) vaccines are typically administered via im
injection to humans and are incapable of inducing respiratory mucosal immunity. However …

Introduction As underlined by the late 2019 outbreak of severe acute respiratory syndrome-
coronavirus-2 (SARS-CoV-2), vaccination remains the cornerstone of global health-care …

Severe respiratory viral infections, such as influenza, metapneumovirus (HMPV), respiratory
syncytial virus (RSV), rhinovirus (RV), and coronaviruses, including severe acute respiratory …

The development of vaccines has always been an essential task worldwide since vaccines
are regarded as powerful weapons in protecting the global population. Although the vast …

Based on mucosal immunization to promote both mucosal and systemic immune responses,
next-generation coronavirus disease 2019 (COVID-19) vaccines would be administered …