Spatiotemporal dynamics of high-K+-induced epileptiform discharges in hippocampal slice and the effects of valproate
JS Liu, JB Li, XW Gong, HQ Gong, PM Zhang… - Neuroscience …, 2013 - Springer
The epileptic seizure is a dynamic process involving a rapid transition from normal activity to
a state of hypersynchronous neuronal discharges. Here we investigated the network …
a state of hypersynchronous neuronal discharges. Here we investigated the network …
Dynamics of epileptiform activity in mouse hippocampal slices
G Filatov, GP Krishnan, NF Rulkov… - Journal of biological …, 2011 - Springer
Increase of the extracellular K+ concentration mediates seizure-like synchronized activities
in vitro and was proposed to be one of the main factors underlying epileptogenesis in some …
in vitro and was proposed to be one of the main factors underlying epileptogenesis in some …
Characterization of the in vitro propagation of epileptiform electrophysiological activity in organotypic hippocampal slice cultures coupled to 3D microelectrode arrays
M Pisciotta, G Morgavi, H Jahnsen - Brain research, 2010 - Elsevier
Dynamic aspects of the propagation of epileptiform activity have so far received little
attention. With the aim of providing new insights about the spatial features of the propagation …
attention. With the aim of providing new insights about the spatial features of the propagation …
Epileptiform burst activity induced by potassium in the hippocampus and its regulation by GABA-mediated inhibition
SJ Korn, JL Giacchino… - Journal of …, 1987 - journals.physiology.org
Intracellular and extracellular recordings were made from pyramidal neurons in
hippocampal slices in order to study spontaneous paroxysmal bursting induced by raising …
hippocampal slices in order to study spontaneous paroxysmal bursting induced by raising …
An in vitro seizure model from human hippocampal slices using multi-electrode arrays
MC Hsiao, PN Yu, D Song, CY Liu, CN Heck… - Journal of neuroscience …, 2015 - Elsevier
Temporal lobe epilepsy is a neurological condition marked by seizures, typically
accompanied by large amplitude synchronous electrophysiological discharges, affecting a …
accompanied by large amplitude synchronous electrophysiological discharges, affecting a …
Depolarization block of neurons during maintenance of electrographic seizures
M Bikson, PJ Hahn, JE Fox… - Journal of …, 2003 - journals.physiology.org
Epileptic seizures are associated with neuronal hyperactivity. Here, however, we
investigated whether continuous neuronal firing is necessary to maintain electrographic …
investigated whether continuous neuronal firing is necessary to maintain electrographic …
Effects of applied electric fields on low-calcium epileptiform activity in the CA1 region of rat hippocampal slices
It is well established that exogenous electric fields can suppress activity obtained in different
models of epileptiform discharge such as penicillin and high potassium. In the low-calcium …
models of epileptiform discharge such as penicillin and high potassium. In the low-calcium …
Ca2+ entry through l-type Ca2+ channels helps terminate epileptiform activity by activation of a Ca2+ dependent afterhyperpolarisation in hippocampal CA3.
RM Empson, JGR Jefferys - Neuroscience, 2001 - Elsevier
In CA3 neurons of disinhibited hippocampal slice cultures the slow afterhyperpolarisation,
following spontaneous epileptiform burst events, was confirmed to be Ca2+ dependent and …
following spontaneous epileptiform burst events, was confirmed to be Ca2+ dependent and …
Epileptogenesis: a new twist on the balance of excitation and inhibition
FE Dudek - Epilepsy currents, 2009 - journals.sagepub.com
Rapid Plasticity at Inhibitory and Excitatory Synapses in the Hippocampus Induced by Ictal
Epileptiform Discharges. Lopantsev V, Both M, Draguhn A. Eur J Neurosci 2009; 29 (6) …
Epileptiform Discharges. Lopantsev V, Both M, Draguhn A. Eur J Neurosci 2009; 29 (6) …
Distinct EEG seizure patterns reflect different seizure generation mechanisms
P Salami, M Lévesque, J Gotman… - Journal of …, 2015 - journals.physiology.org
Low-voltage fast (LVF)-and hypersynchronous (HYP)-seizure onset patterns can be
recognized in the EEG of epileptic animals and patients with temporal lobe epilepsy. Ripples …
recognized in the EEG of epileptic animals and patients with temporal lobe epilepsy. Ripples …