Microglia play pivotal roles in controlling CNS functions in diverse physiological and
pathological contexts, including neuropathic pain, a chronic pain condition caused by …

Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …

Neuropathic pain presents a huge societal and individual burden. The limited efficacy of
current analgesics, diagnostic markers and clinical trial outcome measures arises from an …

Neuropathic pain is a serious consequence of injury or disease in the nervous system itself.
Current treatment options for this condition are often unsatisfactory. From being originally …

Pain is a defense system that responds rapidly to harmful internal and external stimuli
through the somatosensory neuronal pathway. However, damage to the nervous system …

Introduction: Current pharmacotherapeutics for neuropathic pain offer only symptomatic
relief without treating the underlying pathophysiology. Additionally, they are associated with …

In this review, we report existing preclinical evidence on how the CNS compartment as well
as sex affect microglia functions in health. We highlight that recent advances in …

Microglial cells are specialized macrophage cells of the central nervous system responsible
for the innate immunity of the spinal cord and the brain. They protect the brain and spinal …

Neuropathic pain occurring after peripheral nerve injury is not simply a consequence of
temporal continuity of acute nociceptive signals, but rather of maladaptive nervous system …

Microglia are gatekeepers in the CNS for a wide range of pathological stimuli and they blow
the whistle when things go wrong. Collectively, microglia form a CNS tissue alarm system …