Human development requires intricate cell specification and communication pathways that
allow an embryo to generate and appropriately connect more than 200 different cell types …

Ubiquitylation is an essential posttranslational modification that controls cell division,
differentiation, and survival in all eukaryotes. By combining multiple E3 ligases (writers) …

Mammalian development demands precision. Millions of molecules must be properly
located in temporal order, and their function regulated, to orchestrate important steps in cell …

Ubiquitylation is essential for signal transduction as well as cell division and differentiation in
all eukaryotes. Substrate modifications range from a single ubiquitin molecule to complex …

Ubiquitylation is one of the most common post-translational modifications (PTMs) of proteins
that frequently targets substrates for proteasomal degradation. However it can also result in …

Since its discovery as a post-translational signal for protein degradation, our understanding
of ubiquitin (Ub) has vastly evolved. Today, we recognize that the role of Ub signaling is …

Post-translational modification of proteins by ubiquitin is required for nearly all aspects of
eukaryotic cell function. The numerous targets of ubiquitylation, and variety of ubiquitin …

Ubiquitylation is emerging as a versatile device for controlling cellular functions. Here, we
propose that monoubiquitylation is rapidly induced by signalling events and allows the …

Metazoan development from a one-cell zygote to a fully formed organism requires complex
cellular differentiation and communication pathways. To coordinate these processes …

Ubiquitylation (also known as ubiquitination) regulates essentially all of the intracellular
processes in eukaryotes through highly specific modification of numerous cellular proteins …