Translational value of choroid plexus imaging for tracking neuroinflammation in mice and humans

V Fleischer, G Gonzalez-Escamilla… - Proceedings of the …, 2021 - National Acad Sciences
Neuroinflammation is a pathophysiological hallmark of multiple sclerosis and has a close
mechanistic link to neurodegeneration. Although this link is potentially targetable, robust …

Choroid plexus enlargement in inflammatory multiple sclerosis: 3.0-T MRI and translocator protein PET evaluation

VAG Ricigliano, E Morena, A Colombi, M Tonietto… - Radiology, 2021 - pubs.rsna.org
Background Choroid plexuses (CPs) have been suggested as a key gateway for
inflammation in experimental autoimmune encephalitis, but in vivo evidence of their …

The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus

M Schwartz, K Baruch - The EMBO journal, 2014 - embopress.org
Inflammation is an integral part of the body's physiological repair mechanism, unless it
remains unresolved and becomes pathological, as evident in the progressive nature of …

[HTML][HTML] Inflammation of the choroid plexus in progressive multiple sclerosis: accumulation of granulocytes and T cells

S Rodríguez-Lorenzo, J Konings, S Van Der Pol… - Acta neuropathologica …, 2020 - Springer
The choroid plexus (CP) is strategically located between the peripheral blood and the
cerebrospinal fluid, and is involved in the regulation of central nervous system (CNS) …

[HTML][HTML] Choroid plexus enlargement is associated with neuroinflammation and reduction of blood brain barrier permeability in depression

N Althubaity, J Schubert, D Martins, T Yousaf… - NeuroImage: Clinical, 2022 - Elsevier
Background Recent studies have shown that choroid plexuses (CP) may be involved in the
neuro-immune axes, playing a role in the interaction between the central and peripheral …

Clinical implications of leukocyte infiltration at the choroid plexus in (neuro) inflammatory disorders

D Demeestere, C Libert, RE Vandenbroucke - Drug discovery today, 2015 - Elsevier
The choroid plexus (CP) is a highly vascularized organ located in the brain ventricles and
contains a single epithelial cell layer forming the blood–cerebrospinal fluid barrier (BCSFB) …

[HTML][HTML] Tracking calcium dynamics and immune surveillance at the choroid plexus blood-cerebrospinal fluid interface

FB Shipley, N Dani, H Xu, C Deister, J Cui, JP Head… - Neuron, 2020 - cell.com
The choroid plexus (ChP) epithelium is a source of secreted signaling factors in
cerebrospinal fluid (CSF) and a key barrier between blood and brain. Here, we develop …

Association of choroid plexus inflammation on MRI with clinical disability progression over 5 years in patients with multiple sclerosis

N Bergsland, MG Dwyer, D Jakimovski, E Tavazzi… - Neurology, 2023 - AAN Enterprises
Background and Objectives Inflammation of the choroid plexus (CP) has been reported in
multiple sclerosis (MS). The AU1 association between CP inflammation and clinical …

A fully automatic method to segment choroid plexuses in multiple sclerosis using conventional MRI sequences

L Storelli, E Pagani, M Rubin, M Margoni… - Journal of Magnetic …, 2024 - Wiley Online Library
Background Choroid plexus (CP) volume has been recently proposed as a proxy for brain
neuroinflammation in multiple sclerosis (MS). Purpose To develop and validate a fast …

[HTML][HTML] Characterization of age-related differences in the human choroid plexus volume, microstructural integrity, and blood perfusion using multiparameter magnetic …

JSR Alisch, M Kiely, C Triebswetter… - Frontiers in Aging …, 2021 - frontiersin.org
The choroid plexus (CP) is an important cerebral structure involved in cerebrospinal fluid
production and transport of solutes into the brain. Recent studies have uncovered the …