Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions

SC Dyall, L Balas, NG Bazan, JT Brenna… - Progress in lipid …, 2022 - Elsevier
Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids,
and influence cellular function via effects on membrane properties, and also by acting as a …

Targeted lipidomic strategies for oxygenated metabolites of polyunsaturated fatty acids

G Astarita, AC Kendall, EA Dennis… - Biochimica et Biophysica …, 2015 - Elsevier
Oxidation of polyunsaturated fatty acids (PUFA) through enzymatic or non-enzymatic free
radical-mediated reactions can yield an array of lipid metabolites including eicosanoids …

[HTML][HTML] Advances in our understanding of oxylipins derived from dietary PUFAs

M Gabbs, S Leng, JG Devassy, M Monirujjaman… - Advances in …, 2015 - Elsevier
Oxylipins formed from polyunsaturated fatty acids (PUFAs) are the main mediators of PUFA
effects in the body. They are formed via cyclooxygenase, lipoxygenase, and cytochrome …

Eicosanoids in inflammation in the blood and the vessel

A Yamaguchi, E Botta, M Holinstat - Frontiers in pharmacology, 2022 - frontiersin.org
Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids
in cells. PUFAs regulate cellular function through the formation of derived lipid mediators …

Lipidomics of polyunsaturated-fatty-acid-derived oxygenated metabolites

KA Massey, A Nicolaou - Biochemical Society Transactions, 2011 - portlandpress.com
Nutritionally important PUFAs (polyunsaturated fatty acids) mediate some of their
bioactivities through formation of oxygenated metabolites. These bioactive lipids are formed …

Algae: Critical sources of very long-chain polyunsaturated fatty acids

JL Harwood - Biomolecules, 2019 - mdpi.com
Polyunsaturated fatty acids (PUFAs), which are divided into n-3 and n-6 classes, are
essential for good health in humans and many animals. They are metabolised to lipid …

[HTML][HTML] Lipidomics of oxidized polyunsaturated fatty acids

KA Massey, A Nicolaou - Free Radical Biology and Medicine, 2013 - Elsevier
Lipid mediators are produced from the oxidation of polyunsaturated fatty acids through
enzymatic and free radical-mediated reactions. When subject to oxygenation via …

Polyunsaturated fatty acids, part 1: occurrence, biological activities and applications

I Gill, R Valivety - Trends in biotechnology, 1997 - cell.com
Polyunsaturated fatty acids form a unique class of food constituents that show a wide range
of functions in biological systems. Investigations over the past two decades have uncovered …

Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions

A Catalá - Chemistry and physics of lipids, 2009 - Elsevier
Polyunsaturated fatty acids (PUFAs) and their metabolites have a variety of physiological
roles including: energy provision, membrane structure, cell signaling and regulation of gene …

Polyunsaturated fatty acids: conversion to lipid mediators, roles in inflammatory diseases and dietary sources

JL Harwood - International Journal of Molecular Sciences, 2023 - mdpi.com
Polyunsaturated fatty acids (PUFAs) are important components of the diet of mammals. Their
role was first established when the essential fatty acids (EFAs) linoleic acid and α-linolenic …