An Investigation of the Relationship Between Auditory Dysfunctions and Alzheimer's Disease Using Amyloidosis Mouse Models

D Na - 2023 - search.proquest.com
Nearly 10% of the population at 65 years old and older is suffering from Alzheimer's Disease
(AD). The incurability of this neurodegenerative disease is causing a public health crisis …

Increased central auditory gain in 5xFAD Alzheimer's disease mice as an early biomarker candidate for Alzheimer's disease diagnosis

D Na, J Zhang, HJ Beaulac… - Frontiers in …, 2023 - frontiersin.org
Alzheimer's Disease (AD) is a neurodegenerative illness without a cure. All current therapies
require an accurate diagnosis and staging of AD to ensure appropriate care. Central …

[HTML][HTML] Neuroinflammation in a Mouse Model of Alzheimer's Disease versus Auditory Dysfunction: Machine Learning Interpretation and Analysis

D Na, Y Yang, L Xie, D Piekna-Przybylska… - Research …, 2023 - ncbi.nlm.nih.gov
Background Auditory dysfunction, including central auditory hyperactivity, hearing loss and
hearing in noise deficits, has been reported in 5xFAD Alzheimer's disease (AD) mice …

Hearing loss is an early biomarker in APP/PS1 Alzheimer's disease mice

Y Liu, S Fang, LM Liu, Y Zhu, CR Li, K Chen… - Neuroscience letters, 2020 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive
loss of memory and cognitive decline. Over the last decade, it has been found that defects in …

Hearing loss and impaired short-term memory in an Alzheimer's disease mouse model of amyloid-beta pathology

Z Jafari, N Afrashteh, BE Kolb, MH Mohajerani - Experimental Neurology, 2023 - Elsevier
Current evidence supports the link between hearing loss and Alzheimer's disease (AD).
However, few studies report the hearing status of AD mice compared to wild-type mice. This …

Longitudinal analysis of auditory dysfunction in Alzheimer's disease mice 5xFAD

D Na - Alzheimer's & Dementia, 2022 - Wiley Online Library
Background There is no cure for AD at this moment. All available therapies require accurate
diagnosis and staging of AD to ensure proper strategy. Current diagnosis methods rely on …

[HTML][HTML] Auditory brainstem response audiometry in tauopathy mouse model of human Alzheimer's disease

K Burke, LA Screven, S Vicencio-Jimenez… - JASA Express …, 2024 - pubs.aip.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder in which changes in
hearing sensitivity precede cognitive decline. Despite a well-known link between dementia …

[HTML][HTML] Expression of amyloid-β in mouse cochlear hair cells causes an early-onset auditory defect in high-frequency sound perception

Y Omata, S Tharasegaran, YM Lim, Y Yamasaki… - Aging (Albany …, 2016 - ncbi.nlm.nih.gov
Increasing evidence indicates that defects in the sensory system are highly correlated with
age-related neurodegenerative diseases, including Alzheimer's disease (AD). This raises …

Amyloid pathology in the central auditory pathway of 5XFAD mice appears first in auditory cortex

AP Weible, M Wehr - Journal of Alzheimer's Disease, 2022 - content.iospress.com
Background: Effective treatment of Alzheimer's disease (AD) will hinge on early detection.
This has led to the search for early biomarkers that use non-invasive testing. One possible …

Reduced acoustic startle response and peripheral hearing loss in the 5xFAD mouse model of Alzheimer's disease

TP O'Leary, S Shin, E Fertan, RN Dingle… - Genes, Brain and …, 2017 - Wiley Online Library
Hearing dysfunction has been associated with Alzheimer's disease (AD) in humans, but
there is little data on the auditory function of mouse models of AD. Furthermore …