Background Neurologic deficit remains a major complication after cardiovascular surgeries
with deep hypothermic circulatory arrest (DHCA). We hypothesized that exosomes derived …

Background Neuroinflammation acts as a contributor to neurologic deficits after deep
hypothermic circulatory arrest. However, the molecular mechanism remains unclear. This …

Methods: Because the treatment with exosomes has a great potential to overcome the
limitations associated with cell-based therapies, we tested the efficacy of exosomes secreted …

Background Exosomes released into the plasma after brief cardiac ischaemia mediate
subsequent cardioprotection. Whether donor exosomes can provide cardioprotection to …

Exosomes derived from the cerebral endothelial cells play essential roles in protecting
neurons from hypoxia injury, but little is known regarding the biological effects and …

Perioperative organ injury is a frequent and major complication for the∼ 240 million people
undergoing surgery worldwide annually. Ischaemic preconditioning is a powerful technique …

Aims Cerebral ischemic preconditioning is a neuroprotective therapy against cerebral
ischemia and ischemia-reperfusion injury. This study aims to demonstrate the alternation of …

Using deep hypothermic circulatory arrest, thoracic aorta diseases and complex heart
diseases can be subjected to corrective procedures. However, mechanisms underlying …

Objective We investigated the neuroprotection of exosomes derived from bone marrow
mesenchymal stem cells overexpressing microRNA-25 on ischemic spinal cords. Methods …

BACKGROUND Early single-dose treatment with human mesenchymal stem cell–derived
exosomes promotes neuroprotection and promotes blood-brain barrier integrity in models of …