Glioblastoma (GBM) is the most common primary malignant brain tumor in adults.
Regardless of ideal multidisciplinary treatment, including maximal surgical resection …

Background: Gliomas are the most common type of primary brain tumor. Nearly two-thirds of
gliomas are highly malignant lesions that account for a disproportionate share of brain tumor …

Glioblastoma (GBM) is the most deadly form of human cancer. Most patients diagnosed with
this WHO grade IV malignant glioma survive about 12 months. Despite international efforts …

Background The current standard of care for the management of patients with newly
diagnosed glioblastoma (GBM) includes maximal safe resection followed by radiotherapy …

Glioblastoma multiforme is the most common primary brain tumor in adults. Despite major
research efforts and progress in neuroimaging, neurosurgery, and radiation and medical …

Purpose: Rechallenge with temozolomide (TMZ) at first progression of glioblastoma after
temozolomide chemoradiotherapy (TMZ/RT→ TMZ) has been studied in retrospective and …

Importance Despite improvements in survival with aggressive chemoradiation, outcomes for
patients diagnosed as having glioblastoma multiforme (GBM) remain poor. Survival is further …

Age remains the most powerful prognostic factor among glioblastoma (GBM) patients. Half of
all patients with GBM are aged 65 years or older at the time of diagnosis, and the incidence …

Glioma has been considered resistant to chemotherapy and radiation. Recently,
concomitant and adjuvant chemoradiotherapy with temozolomide has become the standard …

Purpose Radiotherapy with concomitant and adjuvant temozolomide is the standard of care
for newly diagnosed glioblastoma (GBM). O6-methylguanine-DNA methyltransferase …