Recent studies have shown that the ephrin/Eph signaling pathway may contribute to the
pathology of neuropathic pain. Drugs like progesterone may be used to counteract both …

Bidirectional signaling between ephrins and Eph receptor tyrosine kinases was first found to
play important roles during development, but recently has been implicated in synaptic …

Ephrin B/EphB signaling pathway is involved in the regulation of pain caused by spinal cord
injury. However, the role of ephrin‐B3/EphBs signaling in regulation of nociceptive …

Background EphB receptors and their ephrinB ligands are implicated in modulating spinal
nociceptive information processing. Here, we investigated whether cyclooxygenase‐2 (COX …

Chronic pain after spinal cord injury represents a therapeutic challenge. Progesterone, a
neuroprotective steroid, has been shown to modulate nociceptive thresholds, whereas its …

In prior studies, Eph/ephrin system was demonstrated to be involved in inflammatory and
neuropathic pain modulation. The present study was to investigate whether the spinal …

Background: EphB receptors and their ephrin-B ligands play an important role in nervous
system development, as well as synapse formation and plasticity in the adult brain. Recent …

EphrinB–EphB receptor signaling plays diverse roles during development, but recently has
been implicated in synaptic plasticity in the matured nervous system and in pain processes …

Background Diabetic neuropathic pain (DNP) is severe and intractable in clinic. The specific
cellular and molecular mechanisms underlying DNP remain elusive and its treatment are …

Progesterone has been shown to have neuroprotective capabilities against a wide range of
nervous system injuries, however there are negative clinical studies that have failed to …