A biosafety level 2 mouse model for studying betacoronavirus-induced acute lung damage and systemic manifestations
ACSP Andrade, GH Campolina-Silva… - Journal of …, 2021 - Am Soc Microbiol
The emergence of life-threatening zoonotic diseases caused by betacoronaviruses,
including the ongoing coronavirus disease 19 (COVID-19) pandemic, has highlighted the …
including the ongoing coronavirus disease 19 (COVID-19) pandemic, has highlighted the …
[HTML][HTML] SARS-CoV-2 variants of concern infect the respiratory tract and induce inflammatory response in wild-type laboratory mice
The emergence of new severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
variants of concern pose a major threat to public health, due to possible enhanced virulence …
variants of concern pose a major threat to public health, due to possible enhanced virulence …
A SCID mouse model to evaluate the efficacy of antivirals against SARS-CoV-2 infection
R Abdelnabi, CS Foo, SJF Kaptein… - Journal of …, 2022 - Am Soc Microbiol
Ancestral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lacks the intrinsic
ability to bind to the mouse ACE2 receptor, and therefore establishment of SARS-CoV-2 …
ability to bind to the mouse ACE2 receptor, and therefore establishment of SARS-CoV-2 …
Mouse hepatitis virus: A betacoronavirus model to study the virucidal activity of air disinfection equipment on surface contamination
GP Oliveira, EG Kroon - Journal of Virological Methods, 2021 - Elsevier
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected millions of
people worldwide. SARS-CoV-2 belongs to the Betacoronavirus genus, containing the …
people worldwide. SARS-CoV-2 belongs to the Betacoronavirus genus, containing the …
[HTML][HTML] Of mice and men: the coronavirus MHV and mouse models as a translational approach to understand SARS-CoV-2
RW Koerner, M Majjouti, MAA Alcazar, E Mahabir - Viruses, 2020 - mdpi.com
The fatal acute respiratory coronavirus disease 2019 (COVID-19) is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Since COVID-19 was declared a …
respiratory syndrome coronavirus 2 (SARS-CoV-2). Since COVID-19 was declared a …
Simulation of the clinical and pathological manifestations of coronavirus disease 2019 (COVID-19) in a golden Syrian hamster model: implications for disease …
Background A physiological small-animal model that resembles COVID-19 with low mortality
is lacking. Methods Molecular docking on the binding between angiotensin-converting …
is lacking. Methods Molecular docking on the binding between angiotensin-converting …
Mouse-Adapted SARS-CoV-2 MA10 Strain Displays Differential Pulmonary Tropism and Accelerated Viral Replication, Neurodissemination, and Pulmonary Host …
CJ Thieulent, W Dittmar, UBR Balasuriya… - Msphere, 2023 - Am Soc Microbiol
Several models were developed to study the pathogenicity of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) as well as the in vivo efficacy of vaccines and …
syndrome coronavirus 2 (SARS-CoV-2) as well as the in vivo efficacy of vaccines and …
[PDF][PDF] A mouse-adapted SARS-CoV-2 induces acute lung injury and mortality in standard laboratory mice
The SARS-CoV-2 pandemic has caused extreme human suffering and economic harm. We
generated and characterized a new mouse-adapted SARS-CoV-2 virus that captures …
generated and characterized a new mouse-adapted SARS-CoV-2 virus that captures …
[HTML][HTML] Common laboratory mice are susceptible to infection with the SARS-CoV-2 beta variant
Small animal models are of crucial importance for assessing COVID-19 countermeasures.
Common laboratory mice would be well-suited for this purpose but are not susceptible to …
Common laboratory mice would be well-suited for this purpose but are not susceptible to …
Humanized mice for investigating SARS‐CoV‐2 lung infection and associated human immune responses
R Sun, Z Zhao, C Fu, Y Wang, Z Guo… - European Journal of …, 2022 - Wiley Online Library
There is an urgent need for animal models of coronavirus disease 2019 to study
immunopathogenesis and test therapeutic intervenes. In this study, we showed that …
immunopathogenesis and test therapeutic intervenes. In this study, we showed that …