Undernutrition-induced substance metabolism and energy production disorders affected the structure and function of the pituitary gland in a pregnant sheep model

S Liu, H Lu, S Mao, Z Zhang, W Zhu, J Cheng… - Frontiers in …, 2023 - frontiersin.org
Introduction Undernutrition spontaneously occurs in ewes during late gestation and the
pituitary is an important hinge in the neurohumoral regulatory system. However, little is …

Periconceptional undernutrition in normal and overweight ewes leads to increased adrenal growth and epigenetic changes in adrenal IGF2/H19 gene in offspring

S Zhang, L Rattanatray, SM MacLaughlin… - The FASEB …, 2010 - Wiley Online Library
Adverse conditions in early life result in increased activation of the hypothalamo‐pituitary‐
adrenal axis and in stress responsiveness in offspring. We have developed a model in …

[HTML][HTML] RNA-sequencing reveals the metabolism regulation mechanism of sheep skeletal muscle under nutrition deprivation stress

J Qin, LR Guo, JL Li, FH Zhang, DP Zhao, R Du - Animal, 2021 - Elsevier
Although the skeletal muscle is one of the main sites of metabolism, little is known about the
molecular mechanisms involving its response to nutrition stress. The aim of the study was to …

A high plane of nutrition during early life alters the hypothalamic transcriptome of heifer calves

JM Sánchez, K Keogh, AK Kelly, CJ Byrne… - Scientific reports, 2021 - nature.com
The aim was to examine the effect of rapid body weight gain during early calfhood consistent
with earlier sexual development on the transcriptional profile of the hypothalamus. Angus X …

Periconceptional undernutrition modifies endocrine profiles and hepatic gene expression in sheep

V De Brun, A Meikle, A Casal… - Journal of animal …, 2015 - Wiley Online Library
This study investigated whether a 22‐day period of undernutrition (half maintenance) could
affect maternal endocrine responses and liver gene expression during early pregnancy (day …

Reproductive hormone and transcriptomic responses of pituitary tissue in anestrus gilts induced by nutrient restriction

S Xu, D Wang, D Zhou, Y Lin, L Che, Z Fang, D Wu - PLoS One, 2015 - journals.plos.org
The onset of estrus is a critical sign of female sexual maturity. The pituitary plays a vital role
in this process by the secretion of reproductive hormones. To investigate the effects of …

Maternal overnutrition during gestation in sheep alters autophagy associated pathways in offspring heart

Y Liu, Q Ding, SJ Halderson, SI Arriola Apelo… - Frontiers in …, 2022 - frontiersin.org
Poor maternal nutrition during gestation can negatively affect offspring growth, development,
and health pre-and post-natally. Overfeeding during gestation or maternal obesity (MO) …

Hypothalamic neuroendocrine circuitry is programmed by maternal obesity: interaction with postnatal nutritional environment

H Chen, D Simar, MJ Morris - PloS one, 2009 - journals.plos.org
Objective Early life nutrition is critical for the development of hypothalamic neurons involved
in energy homeostasis. We previously showed that intrauterine and early postnatal …

Adult-onset obesity reveals prenatal programming of glucose-insulin sensitivity in male sheep nutrient restricted during late gestation

P Rhodes, J Craigon, C Gray, SM Rhind, PT Loughna… - PLoS …, 2009 - journals.plos.org
Background Obesity invokes a range of metabolic disturbances, but the transition from a
poor to excessive nutritional environment may exacerbate adult metabolic dysfunction. The …

Identification of key genes associated with early calf-hood nutrition in subcutaneous and visceral adipose tissues by co-expression analysis

C Pan, C Yang, Y Ma, H Sheng, Z Lei… - Frontiers in Veterinary …, 2022 - frontiersin.org
Background Substantive evidence has confirmed that nutrition state is associated with
health risk and the onset of pubertal and metabolic profile. Due to heterogeneity, adipose …