Regulation of glutathione synthesis

SC Lu - Molecular aspects of medicine, 2009 - Elsevier
Glutathione (GSH) is a ubiquitous intracellular peptide with diverse functions that include
detoxification, antioxidant defense, maintenance of thiol status, and modulation of cell …

Glutathione synthesis

SC Lu - Biochimica et Biophysica Acta (BBA)-General Subjects, 2013 - Elsevier
BACKGROUND: Glutathione (GSH) is present in all mammalian tissues as the most
abundant non-protein thiol that defends against oxidative stress. GSH is also a key …

Regulation of hepatic glutathione synthesis: current concepts and controversies

SC Lu - The FASEB journal, 1999 - Wiley Online Library
Glutathione (GSH) is an important intracellular peptide with multiple functions ranging from
antioxidant defense to modulation of cell proliferation. GSH is synthesized in the cytosol of …

Glutathione: an overview of biosynthesis and modulation

ME Anderson - Chemico-biological interactions, 1998 - Elsevier
Glutathione (GSH; γ-glutamylcysteinylglycine) is ubiquitous in mammalian and other living
cells. It has several important functions, including protection against oxidative stress. It is …

Biologic and pharmacologic regulation of mammalian glutathione synthesis

OW Griffith - Free Radical Biology and Medicine, 1999 - Elsevier
Glutathione (L-γ-glutamyl-L-cysteinylglycine, GSH) is synthesized from its constituent amino
acids by the sequential action of γ-glutamylcysteine synthetase (γ-GCS) and GSH …

[HTML][HTML] Dysregulation of glutathione synthesis in liver disease

SC Lu - Liver Research, 2020 - Elsevier
Glutathione (GSH), a tripeptide that is present in all mammalian tissues, is especially highly
concentrated in the liver. GSH synthesis occurs via two adenosine triphosphate (ATP) …

The importance of glutathione in human disease

DM Townsend, KD Tew, H Tapiero - Biomedicine & pharmacotherapy, 2003 - Elsevier
Reduced glutathione (GSH) is the most prevalent non-protein thiol in animal cells. Its de
novo and salvage synthesis serves to maintain a reduced cellular environment and the …

Regulation of hepatic glutathione synthesis

SC Lu - Seminars in liver disease, 1998 - thieme-connect.com
Glutathione (GSH) is one of the most important intracellular peptides, playing a
multifunctional role ranging from antioxidant defense to modulation of immune function. GSH …

Glutathione homeostasis and functions: potential targets for medical interventions

VI Lushchak - Journal of amino acids, 2012 - Wiley Online Library
Glutathione (GSH) is a tripeptide, which has many biological roles including protection
against reactive oxygen and nitrogen species. The primary goal of this paper is to …

Glutathione dysregulation and the etiology and progression of human diseases

N Ballatori, SM Krance, S Notenboom, S Shi, K Tieu… - 2009 - degruyter.com
Glutathione (GSH) plays an important role in a multitude of cellular processes, including cell
differentiation, proliferation, and apoptosis, and as a result, disturbances in GSH …