Spontaneous solute and solvent permeation through membranes is of vital importance to
human life, be it gas exchange in red blood cells, metabolite excretion, drug/toxin uptake, or …

The biophysical basis of passive membrane permeability is well-understood, but most
methods for predicting membrane permeability in the context of drug design are based on …

This is a review. Non-electrolytic compounds typically cross cell membranes by passive
diffusion. The rate of permeation is dependent on the chemical properties of the solute and …

Diffusion of small nonelectrolytes through planar lipid bilayer membranes (egg
phosphatidylcholine-decane) was examined by correlating the permeability coefficients of …

The ability to predict and interpret membrane permeation coefficients is of critical
importance, particularly because passive transport is crucial for the effective delivery of …

The relationship of solute structure with cellular permeability was probed. Two series of
dipeptide mimetics consisting of glycine, alanine, valine, leucine, phenylalanine, and …

The effect of alkyl chain length on the physicochemical properties of a series of p‐
aminobenzoate esters, determinant of the rate at which they penetrate inert barriers, was …

The Gibbs free energy of dipole or iron permeation of lipid bilayers is calculated as the sum
of all electrostatic, solvophobic and specific interactions. Partitioning models are consistent …

To reach their biological target, drugs have to cross cell membranes, and understanding
passive membrane permeation is therefore crucial for rational drug design. Molecular …

The transport of small molecules across a phospholipid membrane is studied by molecular
dynamics simulations. The effects of size, hydrophobicity, and asphericity of the penetrants …