J. Neurochem.(2010) 115, 1299–1308. Abstract In recent decades, the study of the amyloid
precursor protein (APP) and of its proteolytic products carboxy terminal fragment (CTF), APP …

The amyloid precursor protein (APP) is an ubiquitous receptor-like molecule involved in the
pathogenesis of Alzheimer's disease that generates β-amyloid peptides and causes plaque …

Amyloid precursor protein (APP), which is critically involved in the pathogenesis of
Alzheimer's disease (AD), is cleaved by gamma/epsilon-secretase activity and results in the …

All individuals with Alzheimer's disease (AD) experience a progressive loss of cognitive
function, resulting from a neurodegenerative process characterized by the deposition of ϐ …

For 20 years the amyloid cascade hypothesis of Alzheimer disease (AD) has placed the
amyloid-β peptide (Aβ), formed from the amyloid precursor protein (APP), centre stage in the …

The Amyloid Precursor Protein (APP) has been extensively studied for its role as the
precursor of the β-amyloid protein (Aβ) in Alzheimer's disease (AD). However, our …

In view of the emerging evidence that amyloid-β load in the brain and neuronal deficits are
possibly independent events and the increasing importance of downstream molecular …

The amyloid precursor protein (APP) has occupied a central position in Alzheimer's disease
(AD) pathophysiology, in large part due to the seminal role of amyloid-β peptide (Aβ), a …

Amyloid β-protein precursor (APP), a type I membrane protein, is cleaved by primary α-or β-
secretase and secondary γ-secretase. Cleavage of APP by β-and γ-secretases generates …

The amyloid precursor protein (APP) is an ubiquitous receptor‐like molecule involved in the
pathogenesis of Alzheimer's disease (AD). APP and some of its C‐terminal proteolytic …