Aptamer-targeted photodynamic platforms for tumor therapy

J Yan, T Gao, Z Lu, J Yin, Y Zhang… - ACS applied materials & …, 2021 - ACS Publications
Achieving controlled and accurate delivery of photosensitizers (PSs) into tumor sites is a
major challenge in conventional photodynamic therapy (PDT). Aptamer is a short …

Engineering a cell-surface aptamer circuit for targeted and amplified photodynamic cancer therapy

D Han, G Zhu, C Wu, Z Zhu, T Chen, X Zhang, W Tan - ACS nano, 2013 - ACS Publications
Photodynamic therapy is one of the most promising and noninvasive methods for clinical
treatment of different malignant diseases. Here, we present a novel strategy of designing an …

Assembly of aptamer switch probes and photosensitizer on gold nanorods for targeted photothermal and photodynamic cancer therapy

J Wang, G Zhu, M You, E Song, MI Shukoor, K Zhang… - ACS …, 2012 - ACS Publications
An aptamer switch probe (ASP) linking chlorin e6 (Ce6), a photosensitizer molecule, to the
surface of gold nanorods (AuNRs) was used to target cancer cells for photodynamic therapy …

Tumor microenvironment (TME)-activatable circular aptamer-PEG as an effective hierarchical-targeting molecular medicine for photodynamic therapy

Y Yang, W Zhu, L Cheng, R Cai, X Yi, J He, X Pan… - Biomaterials, 2020 - Elsevier
Photodynamic therapy (PDT) is an effective and noninvasive therapeutic strategy employing
light-triggered singlet oxygen (SO) and reactive oxygen species (ROS) to kill lesional cells …

ATP-activatable photosensitizer enables dual fluorescence imaging and targeted photodynamic therapy of tumor

Y Shen, Q Tian, Y Sun, JJ Xu, D Ye… - Analytical chemistry, 2017 - ACS Publications
Targeted delivery of intracellular stimuli-activatable photosensitizers (PSs) into tumor cells to
achieve selective imaging and on-demand photodynamic therapy (PDT) of tumors has …

[HTML][HTML] Cell specific aptamer-photosensitizer conjugates as a molecular tool in photodynamic therapy

P Mallikaratchy, Z Tang, W Tan - ChemMedChem, 2008 - ncbi.nlm.nih.gov
This paper describes the application of a molecular construct of a photosensitizer and an
aptamer for photo-therapeutically targeting tumor cells. The key step in increasing selectivity …

Nanomaterials-based photosensitizers and delivery systems for photodynamic cancer therapy

XT Yu, SY Sui, YX He, CH Yu, Q Peng - Biomaterials Advances, 2022 - Elsevier
The increasing cancer morbidity and mortality requires the development of high-efficiency
and low-toxicity anticancer approaches. In recent years, photodynamic therapy (PDT) has …

All‐in‐one phototheranostics: single laser triggers NIR‐II fluorescence/photoacoustic imaging guided photothermal/photodynamic/chemo combination therapy

Q Wang, Y Dai, J Xu, J Cai, X Niu… - Advanced Functional …, 2019 - Wiley Online Library
Abstract Development of single near‐infrared (NIR) laser triggered phototheranostics for
multimodal imaging guided combination therapy is highly desirable but is still a big …

A pH reversibly activatable NIR photothermal/photodynamic-in-one agent integrated with renewable nanoimplants for image-guided precision phototherapy

X Zhao, KC Zhao, LJ Chen, YS Liu, JL Liu, XP Yan - Chemical Science, 2021 - pubs.rsc.org
Phototherapy has great potential to revolutionize conventional therapeutic modalities.
However, most phototherapeutic strategies based on multicomponent therapeutic agents …

Development of Sulfonamide‐Functionalized Charge‐Reversal AIE Photosensitizers for Precise Photodynamic Therapy in the Acidic Tumor Microenvironment

X Yang, C Xu, X Zhang, P Li, F Sun… - Advanced Functional …, 2023 - Wiley Online Library
Tumor‐targeted photodynamic therapy (PDT) is desirable as it can achieve efficient killing of
tumor cells with no or less harm to normal cells. Herein, a facile molecular engineering …