Tumor cell invasion and metastasis are associated with the proteolytic activity of various
types of proteinases. Among them, cathepsins, which are lysosomal proteinases, have …

Cathepsins are highly expressed in various human cancers, associated with tumor
metastasis. It is superfamily, concluding A, B, C, D, E, F, G, H, L, K, O, S, V, and W family …

Background Cathepsins represent a group of proteases involved in determining the
metastatic potential of cancer cells. Among these are cysteinyl-(eg cathepsin B and …

Cathepsins are lysosomal peptidases belonging to the papain family, and based on their
catalytic sites, these enzymes can be divided into serine, cysteine and aspartic proteases …

Lysosomal proteinases, cathepsins D, B, and L have been associated with malignant tumor
progression and with prognosis in various human carcinomas. In the current study, the …

Cathepsins are a class of globular proteases, initially described as intracellular peptide
hydrolases, although several cathepsins also have extracellular functions. Cathepsins B, C …

Osteosarcoma is the most frequent malignant bone tumor with a poor survival rate for
patients with metastasis. Previous studies have shown that beside other proteases, distinct …

Cysteine cathepsins are a family of lysosomal proteases that are often upregulated in
various human cancers, and have been implicated in distinct tumorigenic processes such as …

Clinical, biochemical and molecular biology studies have identified lysosome-encapsulated
cellular proteases as critical risk factors for cancer progression. Cathepsins represent a …

Background Most cancers express elevated protease levels which contribute to certain
aspects of tumor behavior such as growth, metastatic spread, and angiogenesis. Elevation …