CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory
Y Kidani, W Nogami, Y Yasumizu… - Proceedings of the …, 2022 - National Acad Sciences
Foxp3-expressing CD25+ CD4+ regulatory T cells (Tregs) are abundant in tumor tissues.
Here, hypothesizing that tumor Tregs would clonally expand after they are activated by …
Here, hypothesizing that tumor Tregs would clonally expand after they are activated by …
Acquisition of suppressive function by conventional T cells limits antitumor immunity upon Treg depletion
SK Whiteside, FM Grant, G Alvisi, J Clarke, L Tang… - Science …, 2023 - science.org
Regulatory T (Treg) cells contribute to immune homeostasis but suppress immune
responses to cancer. Strategies to disrupt Treg cell–mediated cancer immunosuppression …
responses to cancer. Strategies to disrupt Treg cell–mediated cancer immunosuppression …
Fc-optimized anti-CCR8 antibody depletes regulatory T cells in human tumor models
JR Campbell, BR McDonald, PB Mesko, NO Siemers… - Cancer Research, 2021 - AACR
FOXP3+ regulatory T cells (Treg) play a critical role in mediating tolerance to self-antigens
and can repress antitumor immunity through multiple mechanisms. Therefore, targeted …
and can repress antitumor immunity through multiple mechanisms. Therefore, targeted …
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans
D Sugiyama, H Nishikawa, Y Maeda… - Proceedings of the …, 2013 - National Acad Sciences
CD4+ Treg cells expressing the transcription factor FOXP3 (forkhead box P3) are abundant
in tumor tissues and appear to hinder the induction of effective antitumor immunity. A …
in tumor tissues and appear to hinder the induction of effective antitumor immunity. A …
Regulatory T cells in cancer immunotherapy
A Tanaka, S Sakaguchi - Cell research, 2017 - nature.com
FOXP3-expressing regulatory T (Treg) cells, which suppress aberrant immune response
against self-antigens, also suppress anti-tumor immune response. Infiltration of a large …
against self-antigens, also suppress anti-tumor immune response. Infiltration of a large …
Tumor-infiltrating regulatory T cells delineated by upregulation of PD-1 and inhibitory receptors
HJ Park, A Kusnadi, EJ Lee, WW Kim, BC Cho… - Cellular …, 2012 - Elsevier
Foxp3+ regulatory T (Treg) cells are dominant suppressor cells which regulate conventional
T (Tconv) cells. Inside tumor microenvironment, Treg cells have been known to become …
T (Tconv) cells. Inside tumor microenvironment, Treg cells have been known to become …
Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer
MCB Tan, PS Goedegebuure, BA Belt… - The Journal of …, 2009 - journals.aai.org
Tumors evade immune destruction by actively inducing immune tolerance through the
recruitment of CD4+ CD25+ Foxp3+ regulatory T cells (Treg). We have previously described …
recruitment of CD4+ CD25+ Foxp3+ regulatory T cells (Treg). We have previously described …
[HTML][HTML] Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop
Summary Foxp3+ T regulatory (Treg) cells promote immunological tumor tolerance, but how
their immune-suppressive function is regulated in the tumor microenvironment (TME) …
their immune-suppressive function is regulated in the tumor microenvironment (TME) …
Home sweet home: the tumor microenvironment as a haven for regulatory T cells
B Ondondo, E Jones, A Godkin… - Frontiers in immunology, 2013 - frontiersin.org
CD4+ Foxp3+ regulatory T cells (Tregs) have a fundamental role in maintaining immune
balance by preventing autoreactivity and immune-mediated pathology. However this role of …
balance by preventing autoreactivity and immune-mediated pathology. However this role of …
[HTML][HTML] Cutting edge: epigenetic regulation of Foxp3 defines a stable population of CD4+ regulatory T cells in tumors from mice and humans
CD4+ regulatory T cells (Tregs) are critical for maintaining self-tolerance and function to
prevent autoimmune disease. High densities of intratumoral Tregs are generally associated …
prevent autoimmune disease. High densities of intratumoral Tregs are generally associated …