Foxp3-expressing CD25+ CD4+ regulatory T cells (Tregs) are abundant in tumor tissues.
Here, hypothesizing that tumor Tregs would clonally expand after they are activated by …

Regulatory T (Treg) cells contribute to immune homeostasis but suppress immune
responses to cancer. Strategies to disrupt Treg cell–mediated cancer immunosuppression …

FOXP3+ regulatory T cells (Treg) play a critical role in mediating tolerance to self-antigens
and can repress antitumor immunity through multiple mechanisms. Therefore, targeted …

CD4+ Treg cells expressing the transcription factor FOXP3 (forkhead box P3) are abundant
in tumor tissues and appear to hinder the induction of effective antitumor immunity. A …

FOXP3-expressing regulatory T (Treg) cells, which suppress aberrant immune response
against self-antigens, also suppress anti-tumor immune response. Infiltration of a large …

Foxp3+ regulatory T (Treg) cells are dominant suppressor cells which regulate conventional
T (Tconv) cells. Inside tumor microenvironment, Treg cells have been known to become …

Tumors evade immune destruction by actively inducing immune tolerance through the
recruitment of CD4+ CD25+ Foxp3+ regulatory T cells (Treg). We have previously described …

Summary Foxp3+ T regulatory (Treg) cells promote immunological tumor tolerance, but how
their immune-suppressive function is regulated in the tumor microenvironment (TME) …

CD4+ Foxp3+ regulatory T cells (Tregs) have a fundamental role in maintaining immune
balance by preventing autoreactivity and immune-mediated pathology. However this role of …

CD4+ regulatory T cells (Tregs) are critical for maintaining self-tolerance and function to
prevent autoimmune disease. High densities of intratumoral Tregs are generally associated …