Streamlining of prehospital stroke management: the golden hour
Thrombolysis with alteplase administered within a narrow therapeutic window provides an
effective therapy for acute ischaemic stroke. However, mainly because of prehospital delay …
effective therapy for acute ischaemic stroke. However, mainly because of prehospital delay …
Mobile stroke units for prehospital thrombolysis, triage, and beyond: benefits and challenges
In acute stroke management, time is brain. Bringing swift treatment to the patient, instead of
the conventional approach of awaiting the patient's arrival at the hospital for treatment, is a …
the conventional approach of awaiting the patient's arrival at the hospital for treatment, is a …
Implementation and outcome of thrombolysis with alteplase 3–4· 5 h after an acute stroke: an updated analysis from SITS-ISTR
N Ahmed, N Wahlgren, M Grond, M Hennerici… - The Lancet …, 2010 - thelancet.com
Summary Background In September, 2008, the European Acute Stroke Study III (ECASS III)
randomised trial and the Safe Implementation of Treatment in Stroke-International Stroke …
randomised trial and the Safe Implementation of Treatment in Stroke-International Stroke …
Stroke treatment with alteplase given 3· 0–4· 5 h after onset of acute ischaemic stroke (ECASS III): additional outcomes and subgroup analysis of a randomised …
E Bluhmki, Á Chamorro, A Dávalos, T Machnig… - The Lancet …, 2009 - thelancet.com
Summary Background In the European Cooperative Acute Stroke Study III (ECASS III),
alteplase administered 3· 0–4· 5 h after the onset of stroke symptoms resulted in a significant …
alteplase administered 3· 0–4· 5 h after the onset of stroke symptoms resulted in a significant …
Functional outcomes of pre-hospital thrombolysis in a mobile stroke treatment unit compared with conventional care: an observational registry study
A Kunz, M Ebinger, F Geisler, M Rozanski… - The Lancet …, 2016 - thelancet.com
Background Specialised CT-equipped mobile stroke treatment units shorten time to
intravenous thrombolysis in acute ischaemic stroke by starting treatment before hospital …
intravenous thrombolysis in acute ischaemic stroke by starting treatment before hospital …
Tenecteplase versus alteplase for the management of acute ischaemic stroke in Norway (NOR-TEST 2, part A): a phase 3, randomised, open-label, blinded endpoint …
CE Kvistad, H Næss, BH Helleberg, T Idicula… - The Lancet …, 2022 - thelancet.com
Background Tenecteplase is a modified tissue plasminogen activator with pharmacological
and practical advantages over alteplase—which is currently the only approved thrombolytic …
and practical advantages over alteplase—which is currently the only approved thrombolytic …
Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials
KR Lees, E Bluhmki, R Von Kummer, TG Brott, D Toni… - The Lancet, 2010 - thelancet.com
Background Early administration of intravenous recombinant tissue plasminogen activator (rt-
PA) after ischaemic stroke improves outcome. Previous analysis of combined data from …
PA) after ischaemic stroke improves outcome. Previous analysis of combined data from …
Future directions of acute ischaemic stroke therapy
M Fisher, JL Saver - The Lancet Neurology, 2015 - thelancet.com
For several years, the only therapy with proven efficacy for acute ischaemic stroke was
alteplase, which is approved for use within 4· 5 h after stroke onset in many countries, but …
alteplase, which is approved for use within 4· 5 h after stroke onset in many countries, but …
FASTER (Face, Arm, Speech, Time, Emergency Response): experience of Central Coast Stroke Services implementation of a pre-hospital notification system for …
W O'Brien, D Crimmins, W Donaldson, R Risti… - Journal of Clinical …, 2012 - Elsevier
Despite benefit in acute ischaemic stroke, less than 3% of patients receive tissue
plasminogen activator (tPA) in Australia. The FASTER (Face, Arm, Speech, Time …
plasminogen activator (tPA) in Australia. The FASTER (Face, Arm, Speech, Time …
Comparison of tenecteplase with alteplase for the early treatment of ischaemic stroke in the Melbourne Mobile Stroke Unit (TASTE-A): a phase 2, randomised, open …
Summary Background Mobile stroke units (MSUs) equipped with a CT scanner reduce time
to thrombolytic treatment and improve patient outcomes. We tested the hypothesis that …
to thrombolytic treatment and improve patient outcomes. We tested the hypothesis that …