B cell responses: cell interaction dynamics and decisions
JG Cyster, CDC Allen - Cell, 2019 - cell.com
B cells and the antibodies they produce have a deeply penetrating influence on human
physiology. Here, we review current understanding of how B cell responses are initiated; the …
physiology. Here, we review current understanding of how B cell responses are initiated; the …
[HTML][HTML] Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses
Vaccines generate high-affinity antibodies by recruiting antigen-specific B cells to germinal
centers (GCs), but the mechanisms governing the recruitment to GCs on secondary …
centers (GCs), but the mechanisms governing the recruitment to GCs on secondary …
Intrinsic properties of human germinal center B cells set antigen affinity thresholds
K Kwak, N Quizon, H Sohn, A Saniee… - Science …, 2018 - science.org
Protective antibody responses to vaccination or infection depend on affinity maturation, a
process by which high-affinity germinal center (GC) B cells are selected on the basis of their …
process by which high-affinity germinal center (GC) B cells are selected on the basis of their …
[HTML][HTML] When designing vaccines, consider the starting material: the human B cell repertoire
C Havenar-Daughton, RK Abbott, WR Schief… - Current opinion in …, 2018 - Elsevier
Highlights•Antigen-specific naive human B cell repertoire analysis as clinical trial
prelude.•Protein-specific and epitope-specific quantitation of B cells before antigen …
prelude.•Protein-specific and epitope-specific quantitation of B cells before antigen …
The shaping of a B cell pool maximally responsive to infections
N Baumgarth - Annual review of immunology, 2021 - annualreviews.org
B cell subsets differ in development, tissue distribution, and mechanisms of activation. In
response to infections, however, all can differentiate into extrafollicular plasmablasts that …
response to infections, however, all can differentiate into extrafollicular plasmablasts that …
Factors in B cell competition and immunodominance
The majority of all vaccines work by inducing protective antibody responses. The
mechanisms by which the B cells responsible for producing protective antibodies are elicited …
mechanisms by which the B cells responsible for producing protective antibodies are elicited …
B cell activation and response regulation during viral infections
JH Lam, FL Smith, N Baumgarth - Viral immunology, 2020 - liebertpub.com
Acute viral infections are characterized by rapid increases in viral load, leading to cellular
damage and the resulting induction of complex innate and adaptive antiviral immune …
damage and the resulting induction of complex innate and adaptive antiviral immune …
Transcriptional and metabolic control of memory B cells and plasma cells
TJ Ripperger, D Bhattacharya - Annual Review of Immunology, 2021 - annualreviews.org
For many infections and almost all vaccines, neutralizing-antibody-mediated immunity is the
primary basis and best functional correlate of immunological protection. Durable long-term …
primary basis and best functional correlate of immunological protection. Durable long-term …
B-1 cell responses to infections
FL Smith, N Baumgarth - Current opinion in immunology, 2019 - Elsevier
Highlights•Unique developmental paths generate self-reactive B-1 constraint in BCR
responses.•Extensive repertoire shaping of B-1 cells for months after birth.•Accumulating …
responses.•Extensive repertoire shaping of B-1 cells for months after birth.•Accumulating …
Techniques to study antigen-specific B cell responses
J Boonyaratanakornkit, JJ Taylor - Frontiers in immunology, 2019 - frontiersin.org
Antibodies against foreign antigens are a critical component of the overall immune response
and can facilitate pathogen clearance during a primary infection and also protect against …
and can facilitate pathogen clearance during a primary infection and also protect against …