Overexpression of ErbB2, a receptor-like tyrosine kinase, is shared by several types of
human carcinomas. In breast tumors the extent of overexpression has a prognostic value …

ErbB2 is a receptor tyrosine kinase whose activity in normal cells depends on dimerization
with another ligand-binding ErbB receptor. In contrast, amplification of c-erbB2 in tumors …

Abstract Overexpression of the ErbB2/Her2 receptor tyrosine kinase in breast cancers is
associated with the most aggressive tumors. Experimental studies have revealed that ErbB2 …

Receptor tyrosine kinases of the ErbB family are implicated in a number of cancers,
including that of the breast. ErbB receptors are activated by ligand-induced formation of …

ERBB3, a member of the epidermal growth factor receptor (EGFR) family, is unique in that its
tyrosine kinase domain is functionally defective. It is activated by neuregulins, by other …

ErbB (also termed HER) receptors are expressed in various tissues of epithelial,
mesenchymal and neuronal origin, in which they are involved in the control of diverse …

Publisher Summary This chapter focuses on the role played by ErbB receptors in cancer
progression. Cancer patients, whose tumors have alterations in ErbB1 or ErbB2, tend to …

It is well established that the epidermal growth factor (EGF) receptor, receptor tyrosine-
protein kinase erbB-2 (ERBB2)/human EGF receptor 2 (HER2), and, to a lesser extent …

Human epidermal growth factor receptor-2 (HER2/erbB-2) belongs to a family of four
transmembrane receptors involved in signal transduction pathways that regulate cell growth …

The human epidermal growth factor receptor (EGFR) family consists of four members that
belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated …