Microglia are the primary immune cells of the CNS, carrying out key homeostatic roles and
undergoing context-dependent and temporally regulated changes in response to injury and …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by a non-
cell autonomous motor neuron loss. While it is generally believed that the disease onset …

The central nervous system (CNS) is equipped with a variety of cell types, all of which are
assigned particular roles during the development, maintenance, function and repair of …

Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous disorder characterized by
loss of motor neurons, resulting in paralysis and death. Multiple mechanisms of motor …

The prevailing motor neuron-centric view of amyotrophic lateral sclerosis (ALS)
pathogenesis could be an important factor in the failure to identify disease-modifying therapy …

Neurodegenerative disorders are characterized by the selective vulnerability and
progressive loss of discrete neuronal populations. Non-neuronal cells appear to significantly …

Amyotrophic lateral sclerosis is a devastating motor neuron disorder. Traditionally regarded
as a 'neuron only'disease, recent evidence suggested that other cells contribute critically to …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with
selective loss of upper and lower motor neurons. At sites of motor neuron injury …

Amyotrophic lateral sclerosis (ALS) is the most common and most aggressive form of adult
motor neuron (MN) degeneration. The cause of the disease is still unknown, but some …

Microglia and peripheral macrophages have both been implicated in amyotrophic lateral
sclerosis (ALS), although their respective roles have yet to be determined. We now show …