Profile of estetrol, a promising native estrogen for oral contraception and the relief of climacteric symptoms of menopause
C Gérard, JF Arnal, M Jost, J Douxfils… - Expert review of …, 2022 - Taylor & Francis
Introduction Estrogens used in women's healthcare have been associated with increased
risks of venous thromboembolism (VTE) and breast cancer. Estetrol (E4), an estrogen …
risks of venous thromboembolism (VTE) and breast cancer. Estetrol (E4), an estrogen …
The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation
A Abot, C Fontaine, M Buscato, R Solinhac… - EMBO molecular …, 2014 - embopress.org
Estetrol (E4) is a natural estrogen with a long half‐life produced only by the human fetal liver
during pregnancy. The crystal structures of the estrogen receptor α (ER α) ligand‐binding …
during pregnancy. The crystal structures of the estrogen receptor α (ER α) ligand‐binding …
Estetrol: from preclinical to clinical pharmacology and advances in the understanding of the molecular mechanism of action
C Gérard, JM Foidart - Drugs in R&D, 2023 - Springer
Estetrol (E4) is the most recently described natural estrogen. It is produced by the human
fetal liver during pregnancy and its physiological function remains unclear. E4 is the …
fetal liver during pregnancy and its physiological function remains unclear. E4 is the …
[PDF][PDF] Estetrol is a weak estrogen antagonizing estradiol-dependent mammary gland proliferation
C Gérard, S Blacher, L Communal, A Courtin… - J Endocrinol, 2015 - academia.edu
Estetrol (E4) is a natural estrogen produced exclusively by the human fetal liver during
pregnancy. Its physiological activity remains unknown. In contrast to ethinyl estradiol and …
pregnancy. Its physiological activity remains unknown. In contrast to ethinyl estradiol and …
Estetrol: a new choice for contraception
F Fruzzetti, T Fidecicchi, MM Montt Guevara… - Journal of Clinical …, 2021 - mdpi.com
Estetrol (E4) is a natural estrogenic steroid that is normally produced by human fetal liver.
Recent research has demonstrated that it is a potent, orally bioavailable, natural selective …
Recent research has demonstrated that it is a potent, orally bioavailable, natural selective …
[HTML][HTML] Combined estrogenic and anti-estrogenic properties of estetrol on breast cancer may provide a safe therapeutic window for the treatment of menopausal …
C Gérard, M Mestdagt, E Tskitishvili, L Communal… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Increased risk of breast cancer is a critical side effect associated with the use of a
menopausal hormone therapy (MHT). Estetrol (E4) is a natural estrogen produced by the …
menopausal hormone therapy (MHT). Estetrol (E4) is a natural estrogen produced by the …
Estetrol review: profile and potential clinical applications
HJT Coelingh Bennink, CF Holinka, E Diczfalusy - Climacteric, 2008 - Taylor & Francis
In this review paper, the existing information on the human fetal steroid estetrol (E4) has
been summarized. In the past, E4 was considered as a weak estrogen and interest …
been summarized. In the past, E4 was considered as a weak estrogen and interest …
Unique effects on hepatic function, lipid metabolism, bone and growth endocrine parameters of estetrol in combined oral contraceptives
M Mawet, C Maillard, C Klipping… - … European Journal of …, 2015 - Taylor & Francis
Objectives Estetrol (E 4) is a natural estrogen produced by the human fetal liver. In
combination with drospirenone (DRSP) or levonorgestrel (LNG), E 4 blocks ovulation and …
combination with drospirenone (DRSP) or levonorgestrel (LNG), E 4 blocks ovulation and …
Estetrol and mammary gland: friends or foes?
A Gallez, I Dias Da Silva, V Wuidar, JM Foidart… - Journal of Mammary …, 2021 - Springer
Estrogens have pleiotropic effects on many reproductive and non-reproductive tissues and
organs including the mammary gland, uterus, ovaries, vagina, and endothelium. Estrogen …
organs including the mammary gland, uterus, ovaries, vagina, and endothelium. Estrogen …
Antiestrogenic effects of the fetal estrogen estetrol in women with estrogen-receptor positive early breast cancer
CF Singer, HJTC Bennink, C Natter, S Steurer… - …, 2014 - academic.oup.com
Estetrol (E4) is a fetal estrogen with estrogenic effects on reproductive organs and bone in
preclinical models and in postmenopausal women. However, E4 exerts antiestrogenic …
preclinical models and in postmenopausal women. However, E4 exerts antiestrogenic …