The biological fingerprint of environmental adversity may be key to understanding health
and disease, as it encompasses the damage induced as well as the compensatory reactions …

We endeavored to identify objective blood biomarkers for pain, a subjective sensation with a
biological basis, using a stepwise discovery, prioritization, validation, and testing in …

Epidemiological studies indicate a combined contribution of genetic and environmental
factors, mainly exposure to adverse life events, in the risk for psychiatric disease …

Mood disorders (depression, bipolar disorders) are prevalent and disabling. They are also
highly co-morbid with other psychiatric disorders. Currently there are no objective measures …

Introduction: Depression and posttraumatic stress disorder (PTSD) are two complex and
debilitating psychiatric disorders that result in poor life and destructive behaviors against self …

Antidepressants have been shown to improve longevity in C. elegans. It is plausible that
orthologs of genes involved in mood regulation and stress response are involved in such an …

As for most common disorders, the pathogenic forces underlying psychiatric disorders are
complex, with both environmental and genetic factors contributing to risk [1]. For a series of …

Functional genomics strategies have been slow to penetrate research on human stress and
coping, but recent conceptual advances have yielded a raft of new findings relating social …

Epidemiologic and genetic studies suggest common environmental and genetic risk factors
for a number of psychiatric disorders, including depression, bipolar disorder, and …

Stress responses and related outcomes vary markedly across individuals. Elucidating the
molecular underpinnings of this variability is of great relevance for developing individualized …